“Draft:GOLGA8H”的意思、由来-开放百科全书

Golgin subfamily A member 8H, also known as GOLGA8H, is a protein that in humans is encoded by the GOLGA8H gene. Function of the GOLGA8H involves a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. {{AFC submission|t||ts=20190224223626|u=Yellowwiggle|ns=118|demo=}}

Function

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi apparatus and microtubules are thought to be important for the reorganization of the Golgi apparatus after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi apparatus At this point, the function of GOLGA8H itself is not yet well understood by the scientific community.

Expression

GOLGA8H in Homo sapiens has the strongest expression is through the thyroid and testis, with RKPMs of 12.2 and 12.1 respectively, though it is also expressed in lesser amounts in 25 other tissues^[1].

Gene

GOLGA8H is located on the long (q) arm on chromosome 15 in the q13.2 region, from base pair 30,707,438 to base pair 30,718,289 on the forward leading strand^[2].

Interactions

Homologs

Orthologs:

Orthologs of the GOLGA8H gene are present in a wide range of organisms in eukaryotes and archaea, but not bacteria^[1]. These organisms and Homo sapiens diverged from the same node ranging from 29MYA in mammals to 4290MYA in a member of the Archaea domain. The ortholog similarity from the human protein ranges from 35-70% range regardless of the date of divergence. Thus, it would be reasonable to doubt that the GOLGA8H gene and protein is highly conserved.

Paralogs:

Paralogs of the GOLGA8H gene in Homo sapiens have been found in the following genes with over 90% similarity to GOLGA8H^[4]:

Splice Variants

1. ^¹{{Cite web|url=https://www.ncbi.nlm.nih.gov/gene/728498|title=GOLGA8H golgin A8 family member H [Homo sapiens (human)] - Gene - NCBI|website=www.ncbi.nlm.nih.gov|access-date=2019-02-24}}
2. ^{{Cite web|url=http://useast.ensembl.org/Homo_sapiens/Location/View?db=core;g=ENSG00000261794;r=15:30604126-30614561;t=ENST00000566740|title=Chromosome 15: 30,604,126-30,614,561 - Region in detail - Homo sapiens - Ensembl genome browser 95|website=useast.ensembl.org|access-date=2019-02-24}}
3. ^{{Cite web|url=http://amp.pharm.mssm.edu/Harmonizome/gene_set/GOLGA8H/Pathway+Commons+Protein-Protein+Interactions|title=Gene Set - GOLGA8H|website=amp.pharm.mssm.edu|access-date=2019-02-24}}
4. ^{{Cite web|url=https://blast.ncbi.nlm.nih.gov/Blast.cgi|title=BLAST: Basic Local Alignment Search Tool|website=blast.ncbi.nlm.nih.gov|access-date=2019-02-24}}
5. ^{{Cite web|url=http://useast.ensembl.org/Homo_sapiens/Gene/Splice?db=core;g=ENSG00000261794;r=15:30604126-30614561;t=ENST00000566740|title=Gene: GOLGA8H (ENSG00000261794) - Splice variants - Homo sapiens - Ensembl genome browser 95|website=useast.ensembl.org|access-date=2019-03-04}}