| 词条 | Draft:Jonathan N. Thon, Ph.D. |
| 释义 |
| name = Jonathan Thon, PhD. | image = | birth_date = 25 October, 1981 | birth_place = Buenos Aires, Argentina | residence = Cambridge, Massachusetts | nationality = Canadian | alma_mater = McMaster University, Hamilton, Ontario The University of British Columbia, Vancouver | years_active = 2008 - Present | title = Co-founder, Platelet BioGenesis }}Jonathan N. Thon is a Canadian scientist, entrepreneur and educator known for his expertise in the physiology and production of human platelets. He is the co-founder and CEO of Platelet BioGenesis Inc. of Cambridge, Massachusetts, and a lecturer at Harvard Medical School, Boston, Massachusetts.[1] PersonalThon was born October 25, 1981 in Buenos Aires, Argentina. His family immigrated to Toronto, Canada in 1986. He earned his bachelor’s degree in biotechnology and genetic engineering in 2004 from McMaster University, Hamilton, Ontario.[2] In 2008, he earned his Ph.D. in biochemistry and molecular biology from the University of British Columbia, Vancouver.[3] Scientific careerAs an assistant professor in hematology at Brigham and Women’s Hospital, a teaching hospital of Harvard Medical School, Thon’s research focused on the cytoskeletal mechanics and signaling pathways regulating platelet formation in the body, leading to the identification of intermediate stages and triggers of platelet production. Thon’s work led to the discovery of preplatelets, anucleate cells that are an intermediate stage in platelet production.[4][5][6][7] Working with Dr. Joseph Italiano at Brigham and Women’s Hospital, and David A. Weitz, Ph.D. and Linas Mazutis, Ph.D., at Harvard University, Thon co-developed a biomimetic human platelet bioreactor to generate functional human platelets from precursor cells.[8][9][10] This achievement was named #26 on Discover magazine’s Top 100 Stories of 2014.[11] Thon’s work has also led to advances in the elucidation of gene-transcription and protein translation pathways regulating megakaryocyte differentiation; identification of mechanisms regulating the deterioration of platelets in storage; and understanding of other roles platelets play in human disease.[12][13][14][15][16] Platelet BiogenesisThon, Italiano, Linas Mazutis and Sven Karlsson co-founded Platelet BioGenesis in 2014. The company first occupied space in Harvard University’s iLab before moving to LabCentral, a well-known biotechnology incubator in Kendall Square, as a result of winning the Golden Ticket prize sponsored by biotech giant Amgen.[17] It later moved to the Venture Development Center at the University of Massachusetts, Boston. It moved to its current location in the Nest.bio company incubator in Cambridge in 2018. In 2015, Platelet BioGenesis was a recipient of the first round of Milestone Achievement Program Grants awarded by the Massachusetts Life Sciences Center, a quasi-public agency tasked with spurring development in biotechnology in Massachusetts.[18] The company raised $10 million in Series A venture financing in June 2017.[19] The firm has secured grants from the US Department of Defense.[20] Thon joined the firm full-time as CEO and chief scientific officer in August 2017 upon Platelet BioGenesis’ close of their Series A financing round and after securing his green card, enabling him to work full-time in the US.[21] Patents2017, co-inventor, “System and Method for Biomimetic Fluid Processing”[22] 2015, co-inventor, “System and Method for Producing Blood Platelets” (pending)[22] 2013, co-inventor, “System and Method for Biomimetic Fluid Processing”[23] Awards2015, Arch Award, McMaster University[24] 2011, Honorary Medal of Graduation, Kitasato University[25] 2009, Young Investigator Research Award, The International Society of Thrombosis and Haemostasis[26] References1. ^{{Cite web|url=https://connects.catalyst.harvard.edu/Profiles/display/Person/57244|title=Jonathan Thon {{!}} Harvard Catalyst Profiles {{!}} Harvard Catalyst|website=connects.catalyst.harvard.edu|access-date=2018-09-18}} 2. ^{{Cite web|url=http://alumni.mcmaster.ca/s/1439/17/interior.aspx?pgid=3916&gid=1&cid=6712|title=Alumni Profiles|website=alumni.mcmaster.ca|language=en|access-date=2018-09-19}} 3. ^{{Cite web|url=https://vdc.umb.edu/2016/07/28/jonathan-thon-we-will-have-a-huge-impact-on-human-health-across-the-globe/|title=Jonathan Thon: "We will have a huge impact on human health across the globe." {{!}} VDC|website=vdc.umb.edu|language=en-US|access-date=2018-09-18}} 4. ^{{Cite journal|last=Thon|first=Jonathan N.|last2=Montalvo|first2=Alejandro|last3=Patel-Hett|first3=Sunita|last4=Devine|first4=Matthew T.|last5=Richardson|first5=Jennifer L.|last6=Ehrlicher|first6=Allen|last7=Larson|first7=Mark K.|last8=Hoffmeister|first8=Karin|last9=Hartwig|first9=John H.|date=2010-11-15|title=Cytoskeletal mechanics of proplatelet maturation and platelet release|journal=The Journal of Cell Biology|volume=191|issue=4|pages=861–874|doi=10.1083/jcb.201006102|issn=1540-8140|pmc=2983072|pmid=21079248}} 5. ^{{Cite journal|last=Thon|first=Jonathan N.|last2=Macleod|first2=Hannah|last3=Begonja|first3=Antonija Jurak|last4=Zhu|first4=Jie|last5=Lee|first5=Kun-Chun|last6=Mogilner|first6=Alex|last7=Hartwig|first7=John H.|last8=Italiano|first8=Joseph E.|date=2012-05-22|title=Microtubule and cortical forces determine platelet size during vascular platelet production|journal=Nature Communications|volume=3|pages=852|doi=10.1038/ncomms1838|issn=2041-1723|pmid=22617292}} 6. ^{{Cite journal|last=Bender|first=Markus|last2=Thon|first2=Jonathan N.|last3=Ehrlicher|first3=Allen J.|last4=Wu|first4=Stephen|last5=Mazutis|first5=Linas|last6=Deschmann|first6=Emoke|last7=Sola-Visner|first7=Martha|last8=Italiano|first8=Joseph E.|last9=Hartwig|first9=John H.|date=2015-01-29|title=Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein|journal=Blood|volume=125|issue=5|pages=860–868|doi=10.1182/blood-2014-09-600858|issn=1528-0020|pmc=4311231|pmid=25411426}} 7. ^{{Cite journal|last=Stritt|first=Simon|last2=Nieswandt|first2=Bernhard|date=2014-09-18|title=In vitro platelets in sight|url=http://www.bloodjournal.org/content/124/12/1849|journal=Blood|language=en|volume=124|issue=12|pages=1849–1850|doi=10.1182/blood-2014-08-592493|issn=0006-4971|pmid=25606626}} 8. ^{{Cite news|url=https://www.bostonmagazine.com/health/2014/07/21/boston-scientists-created-human-platelets-bioreactor/|title=Boston Scientists Created Human Platelets With a Bioreactor|date=2014-07-21|work=Boston Magazine|access-date=2018-09-18|language=en-US}} 9. ^{{Cite journal|last=Feng|first=Qiang|last2=Shabrani|first2=Namrata|last3=Thon|first3=Jonathan N.|last4=Huo|first4=Hongguang|last5=Thiel|first5=Austin|last6=Machlus|first6=Kellie R.|last7=Kim|first7=Kyungho|last8=Brooks|first8=Julie|last9=Li|first9=Feng|date=2014-11-11|title=Scalable generation of universal platelets from human induced pluripotent stem cells|journal=Stem Cell Reports|volume=3|issue=5|pages=817–831|doi=10.1016/j.stemcr.2014.09.010|issn=2213-6711|pmc=4235139|pmid=25418726}} 10. ^{{Cite journal|last=Thon|first=Jonathan N.|last2=Mazutis|first2=Linas|last3=Wu|first3=Stephen|last4=Sylman|first4=Joanna L.|last5=Ehrlicher|first5=Allen|last6=Machlus|first6=Kellie R.|last7=Feng|first7=Qiang|last8=Lu|first8=Shijiang|last9=Lanza|first9=Robert|date=2014-09-18|title=Platelet bioreactor-on-a-chip|journal=Blood|volume=124|issue=12|pages=1857–1867|issn=1528-0020|pmc=4168343|pmid=25606631}} 11. ^{{Cite news|url=http://discovermagazine.com/2015/jan-feb/26-platelet-production-pumped-up|title=Platelet Production, Pumped Up {{!}} DiscoverMagazine.com|work=Discover Magazine|access-date=2018-09-18}} 12. ^{{Cite journal|last=Macaulay|first=Iain C.|last2=Thon|first2=Jonathan N.|last3=Tijssen|first3=Marloes R.|last4=Steele|first4=Brian M.|last5=MacDonald|first5=Bryan T.|last6=Meade|first6=Gerardene|last7=Burns|first7=Philippa|last8=Rendon|first8=Augusto|last9=Salunkhe|first9=Vishal|date=2013-01-03|title=Canonical Wnt signaling in megakaryocytes regulates proplatelet formation|journal=Blood|volume=121|issue=1|pages=188–196|doi=10.1182/blood-2012-03-416875|issn=1528-0020|pmc=3538329|pmid=23160460}} 13. ^{{Cite journal|last=Thon|first=Jonathan N.|last2=Devine|first2=Dana V.|date=December 2007|title=Translation of glycoprotein IIIa in stored blood platelets|journal=Transfusion|volume=47|issue=12|pages=2260–2270|doi=10.1111/j.1537-2995.2007.01455.x|issn=0041-1132|pmid=17714413}} 14. ^{{Cite journal|last=Thon|first=Jonathan N.|last2=Schubert|first2=Peter|last3=Duguay|first3=Marie|last4=Serrano|first4=Katherine|last5=Lin|first5=Shujun|last6=Kast|first6=Juergen|last7=Devine|first7=Dana V.|date=March 2008|title=Comprehensive proteomic analysis of protein changes during platelet storage requires complementary proteomic approaches|journal=Transfusion|volume=48|issue=3|pages=425–435|doi=10.1111/j.1537-2995.2007.01546.x|issn=0041-1132|pmid=18067510}} 15. ^{{Cite journal|last=Thon|first=Jonathan N.|last2=Peters|first2=Christopher G.|last3=Machlus|first3=Kellie R.|last4=Aslam|first4=Rukhsana|last5=Rowley|first5=Jesse|last6=Macleod|first6=Hannah|last7=Devine|first7=Matthew T.|last8=Fuchs|first8=Tobias A.|last9=Weyrich|first9=Andrew S.|date=2012-08-20|title=T granules in human platelets function in TLR9 organization and signaling|journal=The Journal of Cell Biology|volume=198|issue=4|pages=561–574|doi=10.1083/jcb.201111136|issn=1540-8140|pmc=3514030|pmid=22908309}} 16. ^{{Cite journal|last=Thon|first=Jonathan N.|last2=Devine|first2=Matthew T.|last3=Jurak Begonja|first3=Antonija|last4=Tibbitts|first4=Jay|last5=Italiano|first5=Joseph E.|date=2012-09-06|title=High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)--mediated inhibition of platelet production|journal=Blood|volume=120|issue=10|pages=1975–1984|doi=10.1182/blood-2012-04-420968|issn=1528-0020|pmc=3437592|pmid=22665936}} 17. ^{{Cite news|url=https://americanpharmacynews.com/stories/510723660-amgen-awards-golden-ticket-to-platelet-biogenesis|title=Amgen awards Golden Ticket to Platelet BioGenesis|last=Reports|first=American Pharmacy News|access-date=2018-10-02|language=en}} 18. ^{{Cite web|url=https://www.massbio.org/news/blog/massconnect-where-are-they-now-144374|title=MassCONNECT: WHERE ARE THEY NOW? - Massachusetts Biotechnology Council|website=www.massbio.org|language=en|access-date=2018-10-02}} 19. ^{{Cite web|url=https://www.biocentury.com/bc-extra/financial-news/2017-06-09/platelet-biogenesis-raises-10m-series-round|title=BioCentury - Platelet BioGenesis raises $10M series A round|website=www.biocentury.com|language=en|access-date=2018-09-18}} 20. ^{{Cite news|url=https://www.bostonglobe.com/business/2018/06/27/department-defense-gives-biotech-that-making-blood-platelets-from-stem-cells/lSCA92nDDExhPznlkHvNQN/story.html|title=Department of Defense gives $3.5m to biotech making blood platelets from stem cells - The Boston Globe|work=BostonGlobe.com|access-date=2018-09-18}} 21. ^{{Cite web|url=https://www.newamericaneconomy.org/feature/argentinian-immigrant-credits-boston-with-enabling-business-success/|title=Argentinian Immigrant Credits Boston with Enabling Business Success - New American Economy|website=www.newamericaneconomy.org|language=en-US|access-date=2018-09-18|date=2018-08-25}} 22. ^1 {{Cite patent|title=System and method for producing blood platelets|url=https://patents.google.com/patent/CA2998107A1/en|country=CA|number=2998107A1|inventor=Jonathan N. Thon |assignee= Brigham and Women's Hospital |issue-date=2016-01-19|access-date=2018-09-18}} 23. ^{{Cite patent|title=System and method for a biomimetic fluid processing|url=https://patents.google.com/patent/WO2014107240A1/en|country=WO|number=2014107240A1|issue-date=2013-11-20|access-date=2018-09-18|inventor= Joseph Italiano|inventor2=Linas Mazutis|inventor3=Jonathan N. THON|inventor4=David A. Weitz|assignee=Brigham And Women's Hospital, Inc. }} 24. ^{{Cite news|url=https://cfmu.wordpress.com/2015/06/04/2015-mcmaster-alumni-awards/|title=2015 McMaster Alumni Awards|date=2015-06-04|work=CFMU|access-date=2018-09-18|language=en-US}} 25. ^{{Cite web|url=http://www.bwhpublicationsarchives.org/DisplayCRN.aspx?articleid=1948|title=BWH Clinical & Research News|website=www.bwhpublicationsarchives.org|access-date=2018-10-02}} 26. ^{{Cite web|url=https://cdn.ymaws.com/www.isth.org/resource/resmgr/PastMeetingProgramBooks/2009_Final_Program.pdf|title=The International Society on Thrombosis and Haemostats, XXII Congress|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}} |
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