1. History of the PGC

2. Organizational Structure of the PGC
     PGC Workgroups    ADHD Workgroup   Anxiety Disorders (ANX) Workgroup    Autism Spectrum Disorders (AUT) Workgroup    Bipolar Disorders (BIP) Workgroup    Eating Disorders (ED) Workgroup    Major Depressive Disorders (MDD) Workgroup    Obsessive Compulsive Disorders and Tourette Syndrome (OCD/TS) Workgroup    Post-Traumatic Stress Disorder (PTSD) Workgroup    Schizophrenia (SCZ) Workgroup    Substance Use Disorders (SUD) Workgroup  

3. Selected PGC Publications

4. References

The Psychiatric Genomics Consortium (PGC) was established in 2007 with the goal of conducting meta- and mega-analyses of genomic-wide genetic data, with a focus on psychiatric disorders.^[1] The PGC is global effort: more than 800 researchers from all over the world are PGC collaborators, the PGC embraces the tenant of democratic, open science. By facilitating international collaboration, the PGC has created a database of more than 400,000 individuals, enabling participating researchers to discover and publish groundbreaking results that have deepened our understanding of illnesses across the psychiatric spectrum.^[2] The PGC is funded through numerous, international public and private sources, including the NIMH, NIDA, and the Research Council of Norway.^[3] As of 2016, in conjunction with the launch of its third NIMH grant, the group has emphasized the discovery of "actionable" genetic variations, or results that continue to broaden our biological understanding of disorders, inform clinical practice, and contribute to the development of new therapeutic targets.

In addition to being the basis for dozens of scientific publications published in journals such as Nature Genetics and the American Journal of Psychiatry, PGC research has been the subject of news items in publications such as [https://www.theguardian.com/commentisfree/2018/apr/29/revolution-in-our-understaning-of-depression-will-be-life-transforming The Guardian]^[4], Asia One ^[5], [https://www.washingtonpost.com/news/speaking-of-science/wp/2018/02/08/five-major-psychiatric-diseases-have-overlapping-patterns-of-genetic-activity-new-study-shows/?noredirect=on&utm_term=.3567a356009c The Washington Post] ^[6]and [https://www.nytimes.com/2014/07/22/science/650-million-psychiatric-research.html The New York Times] ^[7]

PGC Research has led to [https://scholar.google.com/scholar?start=10&q=psychiatric+genomics+consortium&hl=en&as_sdt=0,34 significant scientific findings]^[8] related to the genomics of mental health, including findings related to schizophrenia, autism, OCD/Tourette's Syndrome, Anxiety, Major Depressive Disorder, Substance Use Disorder, PTSD and Bipolar Disorder.

History of the PGC

The PGC was founded in 2007 with the purpose of uniting researchers around the world for the purposes of conducting meta and mega-analyses of genomic data for psychiatric disorders.

The early studies done by the PGC provided evidence that GWAS studies are an effective way to yield new findings on the genetic causes of psychiatric disorders.

Over the past decade, the PGC has evolved into an organization which has severed as a unifying force in the field of psychiatric genomics, and has published many papers, including a landmark 2014 paper, [https://www.ncbi.nlm.nih.gov/pubmed/25056061 Biological insights from 108 schizophrenia-associated genetic loci]^[9], which has been cited over 2200 times.

Throughout its history, the PGC's overarching goal has been to promote collaboration between researchers in order to rapidly and efficiently increase the body of knowledge about the causes and comorbidities of major psychiatric disorders.

Organizational Structure of the PGC

The PGC consists of a coordinating committee, data access committee, statistical analysis group, CNV group, cross-disorder group, and ten workgroups, each focused on a separate psychiatric disorder or group of disorders. The workgroups have their own steering committees, and these workgoups all abide by the PGC's Memorandum of Understanding, which details PGC data sharing guidelines, with the purposes of promoting collaboration, supporting new projects, data sharing, and achieving the PGC's aims which include increasing knowledge of genetic variation that contributes to psychiatric disorders.

PGC Workgroups

ADHD Workgroup

chaired by Drs. Ben Neale^[10] and Barbara Franke.

Anxiety Disorders (ANX) Workgroup

The ANX Workgroup is chaired by Drs. Jack Hettema, Jürgen Deckert, and Thalia Eley.^[11]

Autism Spectrum Disorders (AUT) Workgroup

The AUT Workgroup is chaired by Drs. Mark Daly, Bernard Devlin, and Anders Børglum.

Bipolar Disorders (BIP) Workgroup

The BIP Workgroup is chaired by Dr. Ole Andreassen.^[12]

Eating Disorders (ED) Workgroup

The ED Workgroup is chaired by Drs. Cynthia Bulik and Gerome Breen.^[13][14]

Major Depressive Disorders (MDD) Workgroup

The MDD Workgroup is chaired by Drs. Andrew McIntosh^[15] and Cathryn Lewis.

Obsessive Compulsive Disorders and Tourette Syndrome (OCD/TS) Workgroup

The OCD/TS Workgroup is chaired by Dr. Carol Mathews.^[16]

Post-Traumatic Stress Disorder (PTSD) Workgroup

The PTSD Workgroup is chaired by Drs. Karestan Koenen,^[17] Kerry Ressler, Israel Liberzon, and Caroline Nievergelt.^[18][19][20]

Schizophrenia (SCZ) Workgroup

The SCZ Workgroup is chaired by Drs. Michael O'Donovan^[21] and James Walters.

Substance Use Disorders (SUD) Workgroup

The SUD Workgroup is chaired by Drs. Arpana Agrawal,^[22] Howard Edenberg,^[23] and Joel Gelernter.^[24][25]

Selected PGC Publications

[https://www.ncbi.nlm.nih.gov/pubmed/?term=%22psychiatric+genomics+consortium%22 PGC primary publications] can be found on PubMed.gov.

[https://www.ncbi.nlm.nih.gov/pubmed/25056061 Biological insights from 108 schizophrenia-associated genetic loci]: This landmark study sheds light on the genetic architecture of SCZ using approaches that had previously been successful for other complex biomedical disorders. The study identified that a third of genetic risk for SCZ could be attributed to common genetic variation of individually small genetic effects.

[https://www.biorxiv.org/content/early/2017/07/24/167577 Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression]: According to [https://www.psychologytoday.com/us/blog/psychiatry-the-people/201804/massive-study-clarifies-genetic-risks-major-depression Psychology Today]^[26],in this paper "published in Nature Genetics (2018), a large consortium of researchers analyzed genetic data from 135,458 people with MDD, compared with 344,901 healthy controls. The genetic data, derived from a variety of sources including prior research databases and commercial sources such as 23andMe, was analyzed using a variety of sophisticated statistical approaches."

This is significant because "as with other medical conditions, understanding the genetics of depression opens up doors for diagnosis, prevention and treatment. As the genetic database expands, research techniques similar to those in the current study can be used to look at other conditions including anxiety disorder and ADHD."

References

• Ikeda Takamasa
• Ikeda Terumasa
• Ikeda Tsunamasa
• Ikeda (Usagi Yojimbo)
• Ikeda-ya incident
• Ike Delock
• Ikeduru
• Ike Eisenmann
• I Keep Coming Back (song)
• I Keep Forgettin'
• I Keep Forgettin
• I Keep Forgettin' (Every Time You're Near)
• I Keep Forgetting
• I Keep Six Honest...
• Ike (Fire Emblem)
• Ike for President
• Ike for president
• Ike Forte
• Ike Frankian
• Ikegami
• Ikegami Kimiko
• Ikegami Line
• Ikegami Station
• Ikegawa, Kochi
• Ike! Godman