| 词条 | Drug titration |
| 释义 |
When a drug has a narrow therapeutic index, titration is especially important, because the range between the dose at which a drug is effective and the dose at which side effects occur is small.[2] Some examples of the types of drugs commonly requiring titration include insulin, anticonvulsants, blood thinners, anti-depressants, and sedatives.[3][4][5] Titrating off of a medication instead of stopping abruptly is recommended in some situations. Glucocorticoids should be tapered after extended use to avoid adrenal insufficiency.[6] Drug titration is also used in phase I of clinical trials. The experimental drug is given in increasing dosages until side effects become intolerable.[7] A clinical trial in which a suitable dose is found is called a dose-ranging study. See also
References1. ^{{cite book | vauthors = Maxwell S | veditors = Walker BR, Colledge NR, Ralston SH, Penman ID | chapter = Chapter 2: Therapeutics and Good Prescribing: Choosing a Dosing Regime | title = Davidson's Principles and Practice of Medicine |date=2013 |publisher=Elsevier Health Sciences |isbn=978-0-7020-5103-6 |pages=34 | chapter-url = https://books.google.com/books?id=W-5kAgAAQBAJ&pg=PA34 }} {{pharm-stub}}2. ^{{cite book | vauthors = Schachter M, Pirmohamed M| veditors = Bennett PN, Brown MJ, Sharma P | chapter = General Pharmacology |title=Clinical Pharmacology |date=2012 |publisher=Elsevier |pages=74–109 |edition=11 |isbn = 978-0-7020-4084-9 }} 3. ^{{cite book | vauthors = Roden DM | chapter = Chapter 5 : Principles of Clinical Pharmacology | veditors = Kasper D, Fauci A, Hauser S, Longo D,Jameson JL, Loscalzo J | title = Principles of Clinical Pharmacology | edition = 19th | isbn = 978-0-07-180215-4 | location = New York, NY | publisher = McGraw-Hill | date = 2014 }} 4. ^{{cite book | veditors = Olson KR, Anderson IB, Benowitz NL, Blanc PD, Clark RF, Kearney TE, Kim-Katz SY, Wu AH | chapter = Section III: Therapeutic Drugs and Antidotes | title = Poisoning & Drug Overdose | edition = 7th | isbn = 978-0-07-183979-2 | location = New York, NY | publisher = McGraw-Hill }} 5. ^{{cite book | vauthors = Kruidering-Hall M, Campbell L | chapter = Chapter 27: Skeletal Muscle Relaxants | veditors = Katzung BG | title = Basic & Clinical Pharmacology | edition = 14th | location = New York, NY | publisher = McGraw-Hill | isbn = 978-1-259-64115-2 }} 6. ^{{cite book | vauthors = Furst DE, Saag KG | veditors = Matteson EL, Curtis MR | chapter = Glucocorticoid withdrawal | title = Treatment Issues in Rheumatology | chapter-url=https://www.uptodate.com/contents/glucocorticoid-withdrawal | website = UpToDate |accessdate=13 June 2018}} 7. ^{{cite web | title = Dose-Response Information to Support Drug Registration | date = November 1994 | work = Guideline for Industry | url = https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM073115.pdf |publisher=FDA |accessdate=13 June 2018}} 1 : Pharmacology |
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