| 释义 |
- Function
- References
- Further reading
{{Orphan|date=March 2018}}{{Infobox_gene}}Ectonucleoside triphosphate diphosphohydrolase 4 is a protein that in humans is encoded by the ENTPD4 gene. [1]FunctionThis gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium ion-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011]. References 1. ^{{cite web| title = Entrez Gene: Ectonucleoside triphosphate diphosphohydrolase 4| url = https://www.ncbi.nlm.nih.gov/gene/9583| accessdate = 2018-03-21}}
Further reading {{refbegin | 30em}}- {{cite journal |vauthors=Biederbick A, Rösser R, Storre J, Elsässer HP |title=The VSFASSQQ motif confers calcium sensitivity to the intracellular apyrase LALP70 |journal=BMC Biochem. |volume=5 |issue= |pages=8 |date=June 2004 |pmid=15200686 |pmc=443525 |doi=10.1186/1471-2091-5-8 |url=}}
- {{cite journal |vauthors=Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL |title=Human variation in alcohol response is influenced by variation in neuronal signaling genes |journal=Alcohol. Clin. Exp. Res. |volume=34 |issue=5 |pages=800–12 |date=May 2010 |pmid=20201926 |doi=10.1111/j.1530-0277.2010.01152.x |url=}}
- {{cite journal |vauthors=Saito A, Fujikura-Ouchi Y, Ito C, Matsuoka H, Shimoda K, Akiyama K |title=An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia |journal=Psychiatry Res |volume=185 |issue=1-2 |pages=9–15 |date=January 2011 |pmid=20537721 |doi=10.1016/j.psychres.2009.09.018 |url=}}
- {{cite journal |vauthors=Saito A, Fujikura-Ouchi Y, Ito C, Matsuoka H, Shimoda K, Akiyama K |title=An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia |journal=Psychiatry Res |volume=185 |issue=1-2 |pages=9–15 |date=January 2011 |pmid=20537721 |doi=10.1016/j.psychres.2009.09.018 |url=}}
{{refend}}{{NLM content}}{{gene-8-stub}} |