| 词条 | 1,1,2-Trichloroethane |
| 释义 |
| Watchedfields = changed | verifiedrevid = 477201733 | Name = 1,1,2-Trichloroethane | ImageFileL1_Ref = {{chemboximage|correct|??}} | ImageFileL1 = 1,1,2-Trichloroethane.svg | ImageNameL1 = 1,1,2-Trichloroethane | ImageFileR1 = 1,1,2-trichloroethane-3D-vdW.png | IUPACName = 1,1,2-Trichloroethane | OtherNames = 1,1,2-TCA vinyl trichloride beta-trichloroethane |Section1={{Chembox Identifiers | PubChem = 6574 | InChI = 1/C2H3Cl3/c3-1-2(4)5/h2H,1H2 | InChIKey = UBOXGVDOUJQMTN-UHFFFAOYAA | SMILES1 = C(C(Cl)Cl)Cl | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 43882 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C2H3Cl3/c3-1-2(4)5/h2H,1H2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = UBOXGVDOUJQMTN-UHFFFAOYSA-N | CASNo = 79-00-5 | CASNo_Ref = {{cascite|correct|CAS}} | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 28E9ERN9WU | SMILES = ClCC(Cl)Cl | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 36018 | ChemSpiderID =6326 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = C19536 |Section2={{Chembox Properties | Formula = C{{sub|2}}H{{sub|3}}Cl{{sub|3}} | MolarMass = 133.40 g/mol | Density = 1.435 g/cm{{sup|3}} | MeltingPtC = -37 | MeltingPt_notes = | BoilingPtC = 110 to 115 | BoilingPt_notes = | Appearance = colorless liquid[1] | Odor = sweet, chloroform-like[1] | Solubility = 0.4% (20°C)[1] | VaporPressure = 19 mmHg (20°C)[1] |Section7={{Chembox Hazards | NFPA-H = 3 | NFPA-F = 1 | NFPA-R = | PEL = TWA 10 ppm (45 mg/m{{sup|3}}) [skin][1] | ExploLimits = 6%-15.5%[1] | IDLH = Ca [100 ppm][1] | REL = Ca TWA 10 ppm (45 mg/m{{sup|3}}) [skin][1] | LCLo = 13,100 mg/m{{sup|3}} (cat, 4.5 hr) 2000 ppm (rat, 4 hr)[2] |Section8={{Chembox Related | OtherCompounds = 1,1,1-Trichloroethane; Trichloroethylene}} }} 1,1,2-Trichloroethane, or 1,1,2-TCA, is an organochloride solvent with the molecular formula C{{sub|2}}H{{sub|3}}Cl{{sub|3}}. It is a colourless, sweet-smelling liquid that does not dissolve in water, but is soluble in most organic solvents. It is an isomer of 1,1,1-trichloroethane. It is used as a solvent and as an intermediate in the synthesis of 1,1-dichloroethane. 1,1,2-TCA is a central nervous system depressant and inhalation of vapors may cause dizziness, drowsiness, headache, nausea, shortness of breath, unconsciousness, or cancer.[10] ToxicologyTrichloroethane may be harmful by inhalation, ingestion and skin contact. It is a respiratory and eye irritant. Although no definitive studies currently exist, trichloroethane should be treated as a potential carcinogen since laboratory evidence suggests that low molecular weight chlorinated hydrocarbons may be carcinogenic.[3] The Occupational Safety and Health Administration and National Institute for Occupational Safety and Health have set occupational exposure limits to 1,1,2-Trichloroethane at 10 ppm over an eight-hour time-weighted average.[4] It is considered to be a potential occupational carcinogen. References1. ^1 2 3 4 5 6 7 {{PGCH|0628}} {{GABAAR PAMs}}{{DEFAULTSORT:Trichloroethane, 1, 1, 2-}}2. ^{{IDLH|79005|1,1,2-Trichloroethane}} 3. ^1 {{cite web | title = Safety (MSDS) data for 1,1,2-trichloroethane |url = https://www.spectrumchemical.com/MSDS/TCI-T0381.pdf}} 4. ^[https://www.cdc.gov/niosh/npg/npgd0628.html CDC - NIOSH Pocket Guide to Chemical Hazards] 3 : Chloroalkanes|Halogenated solvents|GABAA receptor positive allosteric modulators |
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