| 词条 | Eileen Shore |
| 释义 |
| name = Eileen M. Shore | image =Dr Eileen Shore.jpg | birth_place = Newark, New Jersey[1] | nationality = US | fields = Genetics | known_for = Research on connective tissue diseases }} Eileen Shore is an American medical researcher and geneticist specializing in research of muscoskeletal disorders such as fibrodysplasia ossificans progressiva. EducationShore received her bachelor's degree in biology from the University of Notre Dame in 1976. She then earned a Master of Arts in biology at Indiana University in 1978. Subsequently, she received her PhD from the University of Pennsylvania in cell and molecular biology in 1987.[2] FOP researchShore undertakes research into fibrodysplasia ossificans progressiva (FOP), a genetic disease that causes bone tissue to form outside the skeleton, known as heterotopic ossification. In 1992, Shore and Frederick Kaplan initiated the FOP Research Laboratory.[3] Kaplan hired Shore because of her experience as a geneticist—she researched fruit fly larvae as a graduate student and studied mammalian embryology as a postdoctoral researcher.[3] In 2006, Shore and Kaplan published their findings on the genetic mutation that causes FOP[4] as a paper entitled "A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva".[5] The cause of the disease was traced to a single mutation in the activin A receptor, type I gene.[4] Once the cause of the disease was identified, Shore became involved in efforts to control the disease and its symptoms. In 2016, she was coauthor on a paper that explored the efficacy of a drug on mice with the same genetic mutation. The authors concluded that the drug palovarotene showed promise in preventing heterotopic ossification, stating that there was "clear evidence for its encompassing therapeutic potential".[6] As of 2015, Kaplan and Shore were the directors of the Center for Research in FOP and Related Disorders. They are considered the "world's foremost experts on FOP".[7] Awards and honorsShore has been the recipient of several awards, including:[1][8]
Selected publications
References1. ^1 {{cite web|url=http://www.asbmr.org/asset.axd?id=798dc0da-bff5-4ab6-b20b-abc572e3c232&t|title=Shore, Eileen M., Ph.D.| access-date=2 March 2019|website=American Society for Bone and Mineral Research}} {{Authority control}}2. ^{{cite web|url=https://www.med.upenn.edu/apps/faculty/index.php/g275/p9320| title=Eileen M. Shore, Ph.D.| website=Perelman School of Medicine|access-date=2 March 2019}} 3. ^{{cite web|url=https://www.theatlantic.com/magazine/archive/2013/06/the-mystery-of-the-second-skeleton/309305/| title=The Girl Who Turned to Bone| first=Carl|last=Zimmer|date=June 2013|website=The Atlantic|access-date=2 March 2019}} 4. ^1 {{cite web|url=https://www.eurekalert.org/pub_releases/2006-04/uops-prd041906.php| title=Penn researchers discover gene that creates second skeleton | date=23 April 2006| access-date=2 March 2019|author=University of Pennsylvania School of Medicine| website=EurekAlert!}} 5. ^{{cite journal|doi=10.1038/ng1783|pmid=16642017|title=A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva|journal=Nature Genetics|volume=38|issue=5|pages=525–527|year=2006|last1=Shore|first1=Eileen M.|last2=Xu|first2=Meiqi|last3=Feldman|first3=George J.|last4=Fenstermacher|first4=David A.|last5=Cho|first5=Tae-Joon|last6=Choi|first6=In Ho|last7=Connor|first7=J Michael|last8=Delai|first8=Patricia|last9=Glaser|first9=David L.|last10=Lemerrer|first10=Martine|last11=Morhart|first11=Rolf|last12=Rogers|first12=John G.|last13=Smith|first13=Roger|last14=Triffitt|first14=James T.|last15=Urtizberea|first15=J Andoni|last16=Zasloff|first16=Michael|last17=Brown|first17=Matthew A.|last18=Kaplan|first18=Frederick S.}} 6. ^{{cite journal|doi=10.1002/jbmr.2820|pmid=26896819|pmc=4992469|title=Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice with the HumanACVR1R206HFibrodysplasia Ossificans Progressiva (FOP) Mutation|journal=Journal of Bone and Mineral Research|volume=31|issue=9|pages=1666–1675|year=2016|last1=Chakkalakal|first1=Salin A.|last2=Uchibe|first2=Kenta|last3=Convente|first3=Michael R.|last4=Zhang|first4=Deyu|last5=Economides|first5=Aris N.|last6=Kaplan|first6=Frederick S.|last7=Pacifici|first7=Maurizio|last8=Iwamoto|first8=Masahiro|last9=Shore|first9=Eileen M.}} 7. ^1 {{cite web|url=https://www.raredr.com/news/fibrodysplasia-ossificans-progressiva-look-toes| title=Fibrodysplasia Ossificans Progressiva: Before You Biopsy, Look at the Toes| first=Christin| last= Melton|date=3 March 2015| website=Rare Disease Report|access-date=2 March 2019}} 8. ^{{cite web|url=https://www.ifopa.org/upenn_research_team| title=UPenn Research Team| website=ifopa| access-date=2 March 2019}} 8 : Living people|Year of birth missing (living people)|American medical researchers|American women scientists|University of Notre Dame alumni|Indiana University Bloomington alumni|University of Pennsylvania alumni|People from Newark, New Jersey |
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