“12beta-hydroxysteroid dehydrogenase”的意思、由来-开放百科全书

词条

12beta-hydroxysteroid dehydrogenase

释义

References

{{enzyme
| Name = 12-beta-hydroxysteroid dehydrogenase
| EC_number = 1.1.1.238
| CAS_number = 118390-62-8
| IUBMB_EC_number = 1/1/1/238
| GO_code = 0047521
| image =
| width =
| caption =
}}

In enzymology, a 12beta-hydroxysteroid dehydrogenase ({{EC number|1.1.1.238}}) is an enzyme that catalyzes the chemical reaction

3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP⁺ 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H⁺

Thus, the two substrates of this enzyme are 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate and NADP⁺, whereas its 3 products are 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 12beta-hydroxysteroid:NADP⁺ 12-oxidoreductase. Other names in common use include 12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate), and dehydrogenase.

References

{{cite journal |vauthors=Edenharder R, Pfutzner A | date = 1988 | title = Characterization of NADP-dependent 12 beta-hydroxysteroid dehydrogenase from Clostridium paraputrificum | journal = Biochim. Biophys. Acta | volume = 962 | pages = 362–70 | pmid = 3167086 | issue = 3 | doi=10.1016/0005-2760(88)90266-4}}

3 : EC 1.1.1|NADPH-dependent enzymes|Enzymes of unknown structure

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