| 词条 | Endocannabinoid enhancer |
| 释义 |
An endocannabinoid enhancer (eCBE) is a type of cannabinoidergic[1] drug that enhances the activity of the endocannabinoid system by increasing extracellular concentrations of endocannabinoids.[2][3][4][5] Examples of different types of eCBEs include fatty acid amide hydrolase (FAAH) inhibitors, monoacylglycerol lipase (MAGL) inhibitors, and endocannabinoid transporter (eCBT) inhibitors (or "endocannabinoid reuptake inhibitors" ("eCBRIs")).[2][3][4][5] An example of an actual eCBE is AM404, the active metabolite of the analgesic paracetamol (acetaminophen; Tylenol) and a dual FAAH inhibitor and eCBRI.[6][7][8] See also
References1. ^{{cite book|author1=George I. Papakostas|author2=Maurizio Fava|title=Pharmacotherapy for Depression and Treatment-resistant Depression|url=https://books.google.com/books?id=zigp-66vq0MC&pg=PA323|year=2010|publisher=World Scientific|isbn=978-981-4287-59-3|pages=323–}} {{Neuromodulation}}{{Cannabinoids}}{{Cannabinoidergics}}{{DEFAULTSORT:Endocannabinoid Enhancer}}{{Pharmacology-stub}}2. ^1 {{cite journal|last1=Bambico|first1=Francis Rodriguez|last2=Gobbi|first2=Gabriella|title=The cannabinoid CB1 receptor and the endocannabinoid anandamide: possible antidepressant targets|journal=Expert Opinion on Therapeutic Targets|volume=12|issue=11|year=2008|pages=1347–1366|issn=1472-8222|doi=10.1517/14728222.12.11.1347}} 3. ^1 {{cite journal|last1=Di Marzo|first1=Vincenzo|title=Targeting the endocannabinoid system: to enhance or reduce?|journal=Nature Reviews Drug Discovery|volume=7|issue=5|year=2008|pages=438–455|issn=1474-1776|doi=10.1038/nrd2553}} 4. ^1 {{cite journal|last1=Saito|first1=Viviane M.|last2=Wotjak|first2=Carsten T.|last3=Moreira|first3=Fabrício A.|title=Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders?|journal=Rev Bras Psiquiatr|volume=32|issue=1|year=2010|pages=57–514|pmid=20512266|issn=1516-4446|doi=10.1590/S1516-44462010000500004|url=http://www.scielo.br/scielo.php?pid=S1516-44462010000500004&script=sci_arttext&tlng=en}} 5. ^1 {{cite journal|last1=Micale|first1=Vincenzo|last2=Di Marzo|first2=Vincenzo|last3=Sulcova|first3=Alexandra|last4=Wotjak|first4=Carsten T.|last5=Drago|first5=Filippo|title=Endocannabinoid system and mood disorders: Priming a target for new therapies|journal=Pharmacology & Therapeutics|volume=138|issue=1|year=2013|pages=18–37|issn=0163-7258|doi=10.1016/j.pharmthera.2012.12.002|pmid=23261685}} 6. ^{{cite journal | vauthors = Giuffrida A, Beltramo M, Piomelli D | title = Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology | journal = J. Pharmacol. Exp. Ther. | volume = 298 | issue = 1 | pages = 7–14 | year = 2001 | pmid = 11408519 | doi = | url = }} 7. ^{{cite journal | vauthors = Anderson BJ | title = Paracetamol (Acetaminophen): mechanisms of action | journal = Paediatr Anaesth | volume = 18 | issue = 10 | pages = 915–21 | year = 2008 | pmid = 18811827 | doi = 10.1111/j.1460-9592.2008.02764.x | url = }} 8. ^{{cite journal | vauthors = Bertolini A, Ferrari A, Ottani A, Guerzoni S, Tacchi R, Leone S | title = Paracetamol: new vistas of an old drug | journal = CNS Drug Rev | volume = 12 | issue = 3–4 | pages = 250–75 | year = 2006 | pmid = 17227290 | doi = 10.1111/j.1527-3458.2006.00250.x | url = }} 2 : Cannabinoids|Endocannabinoids |
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