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词条 ERB-196
释义

  1. See also

  2. References

  3. External links

{{Drugbox
| Verifiedfields =
| Watchedfields =
| verifiedrevid =
| IUPAC_name = 3-(3-Fluoro-4-hydroxyphenyl)-7-hydroxynaphthalene-1-carbonitrile
| image = ERB-196.svg
| width = 250px
| tradename =
| pregnancy_AU =
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| pregnancy_category =
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| legal_US =
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| routes_of_administration =
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| protein_bound =
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| CAS_number_Ref =
| CAS_number = 550997-55-2
| CAS_supplemental =
| ATC_prefix =
| ATC_suffix =
| ATC_supplemental =
| PubChem = 6102691
| IUPHAR_ligand =
| DrugBank_Ref =
| DrugBank = DB06875
| ChemSpiderID_Ref =
| ChemSpiderID = 4810213
| UNII =
| KEGG =
| ChEBI =
| ChEMBL = 192154
| synonyms = WAY-202196
| C=17 | H=10 | F=1 | N=1 | O=2
| molecular_weight = 279.27 g/mol
| SMILES = C1(=CC2=C(C(=C1)C#N)C=C(C=C2)O)C1=CC(=C(C=C1)O)F
| StdInChI_Ref =
| StdInChI = 1S/C17H10FNO2/c18-16-7-10(2-4-17(16)21)12-5-11-1-3-14(20)8-15(11)13(6-12)9-19/h1-8,20-21H
| StdInChIKey_Ref =
| StdInChIKey = NSSOSHDCWCMNDM-UHFFFAOYSA-N
}}ERB-196, also known as WAY-202196, is a synthetic nonsteroidal estrogen that acts as a highly selective agonist of the ERβ.[1][2][3][4][5][6] It possesses 78-fold selectivity for the ERβ over the ERα.[1] The drug was under development by Wyeth for the treatment of inflammation and sepsis starting in 2004 but development was discontinued by 2011.[2][7]

See also

  • 8β-VE2
  • Diarylpropionitrile
  • FERb 033
  • Prinaberel
  • WAY-166818
  • WAY-200070
  • WAY-214156

References

1. ^{{cite book|author=R. E. Hubbard|title=Structure-based Drug Discovery: An Overview|url=https://books.google.com/books?id=Q_Kj1Qvgob4C&pg=PA241|year=2006|publisher=Royal Society of Chemistry|isbn=978-0-85404-351-4|pages=241–}}
2. ^https://adisinsight.springer.com/drugs/800021229{{dead link|date=December 2016 |bot=InternetArchiveBot |fix-attempted=yes }}
3. ^{{cite book|title=Estrogens—Advances in Research and Application: 2013 Edition: ScholarlyBrief|url=https://books.google.com/books?id=NYW4rG83zrUC&pg=PA52|date=21 June 2013|publisher=ScholarlyEditions|isbn=978-1-4816-8771-3|pages=52–}}
4. ^{{cite book|author1=Eckhard Ottow|author2=Hilmar Weinmann|title=Nuclear Receptors as Drug Targets|url=https://books.google.com/books?id=iATfLbPgRugC&pg=PA66|date=8 September 2008|publisher=John Wiley & Sons|isbn=978-3-527-62330-3|pages=66–}}
5. ^{{cite journal | vauthors = Mewshaw RE, Edsall RJ, Yang C, Manas ES, Xu ZB, Henderson RA, Keith JC, Harris HA | title = ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity | journal = J. Med. Chem. | volume = 48 | issue = 12 | pages = 3953–79 | year = 2005 | pmid = 15943471 | doi = 10.1021/jm058173s | url = }}
6. ^{{cite journal | vauthors = Cristofaro PA, Opal SM, Palardy JE, Parejo NA, Jhung J, Keith JC, Harris HA | title = WAY-202196, a selective estrogen receptor-beta agonist, protects against death in experimental septic shock | journal = Crit. Care Med. | volume = 34 | issue = 8 | pages = 2188–93 | year = 2006 | pmid = 16755255 | doi = 10.1097/01.CCM.0000227173.13497.56 | url = }}
7. ^{{cite book|author=Jean-Louis Vincent|title=Yearbook of Intensive Care and Emergency Medicine 2007|url=https://books.google.com/books?id=zT8_AAAAQBAJ&pg=PA891|date=8 December 2007|publisher=Springer Science & Business Media|isbn=978-3-540-49433-1|pages=891–}}

External links

  • ERB-196 - AdisInsight{{dead link|date=December 2016 |bot=InternetArchiveBot |fix-attempted=yes }}
{{Estrogen receptor modulators}}{{genito-urinary-drug-stub}}

6 : Phenols|Fluoroarenes|Naphthalenes|Nitriles|Selective ERβ agonists|Synthetic estrogens

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