| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}ERCC excision repair 6 like, spindle assembly checkpoint helicase is a protein that in humans is encoded by the ERCC6L gene. [1]FunctionThis gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis. References 1. ^{{cite web| title = Entrez Gene: ERCC excision repair 6 like, spindle assembly checkpoint helicase| url = https://www.ncbi.nlm.nih.gov/gene/54821| accessdate = 2017-07-29}}
Further reading {{refbegin | 2}}- {{cite journal |vauthors=Xu Y, Chen X, Li Y |title=Ercc6l, a gene of SNF2 family, may play a role in the teratogenic action of alcohol |journal=Toxicol. Lett. |volume=157 |issue=3 |pages=233–9 |year=2005 |pmid=15917148 |doi=10.1016/j.toxlet.2005.02.013 |url=}}
- {{cite journal |vauthors=Baumann C, Körner R, Hofmann K, Nigg EA |title=PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint |journal=Cell |volume=128 |issue=1 |pages=101–14 |year=2007 |pmid=17218258 |doi=10.1016/j.cell.2006.11.041 |url=}}
- {{cite journal |vauthors=Spence JM, Phua HH, Mills W, Carpenter AJ, Porter AC, Farr CJ |title=Depletion of topoisomerase IIalpha leads to shortening of the metaphase interkinetochore distance and abnormal persistence of PICH-coated anaphase threads |journal=J. Cell Sci. |volume=120 |issue=Pt 22 |pages=3952–64 |year=2007 |pmid=17956945 |pmc=5500177 |doi=10.1242/jcs.013730 |url=}}
- {{cite journal |vauthors=Leng M, Bessuso D, Jung SY, Wang Y, Qin J |title=Targeting Plk1 to chromosome arms and regulating chromosome compaction by the PICH ATPase |journal=Cell Cycle |volume=7 |issue=10 |pages=1480–9 |year=2008 |pmid=18418076 |doi=10.4161/cc.7.10.5951 |url=}}
- {{cite journal |vauthors=Hübner NC, Wang LH, Kaulich M, Descombes P, Poser I, Nigg EA |title=Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs |journal=Chromosoma |volume=119 |issue=2 |pages=149–65 |year=2010 |pmid=19904549 |pmc=2846388 |doi=10.1007/s00412-009-0244-2 |url=}}
- {{cite journal |vauthors=Kurasawa Y, Yu-Lee LY |title=PICH and cotargeted Plk1 coordinately maintain prometaphase chromosome arm architecture |journal=Mol. Biol. Cell |volume=21 |issue=7 |pages=1188–99 |year=2010 |pmid=20130082 |pmc=2847523 |doi=10.1091/mbc.E09-11-0950 |url=}}
- {{cite journal |vauthors=Ke Y, Huh JW, Warrington R, Li B, Wu N, Leng M, Zhang J, Ball HL, Li B, Yu H |title=PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution |journal=EMBO J. |volume=30 |issue=16 |pages=3309–21 |year=2011 |pmid=21743438 |pmc=3160651 |doi=10.1038/emboj.2011.226 |url=}}
- {{cite journal |vauthors=Rouzeau S, Cordelières FP, Buhagiar-Labarchède G, Hurbain I, Onclercq-Delic R, Gemble S, Magnaghi-Jaulin L, Jaulin C, Amor-Guéret M |title=Bloom's syndrome and PICH helicases cooperate with topoisomerase IIα in centromere disjunction before anaphase |journal=PLoS ONE |volume=7 |issue=4 |pages=e33905 |year=2012 |pmid=22563370 |pmc=3338505 |doi=10.1371/journal.pone.0033905 |url=}}
- {{cite journal |vauthors=Biebricher A, Hirano S, Enzlin JH, Wiechens N, Streicher WW, Huttner D, Wang LH, Nigg EA, Owen-Hughes T, Liu Y, Peterman E, Wuite GJ, Hickson ID |title=PICH: a DNA translocase specially adapted for processing anaphase bridge DNA |journal=Mol. Cell |volume=51 |issue=5 |pages=691–701 |year=2013 |pmid=23973328 |pmc=4161920 |doi=10.1016/j.molcel.2013.07.016 |url=}}
{{refend}}{{NLM content}}{{gene-X-stub}} |