“15-hydroxyprostaglandin-I dehydrogenase (NADP+)”的意思、由来-开放百科全书

词条

15-hydroxyprostaglandin-I dehydrogenase (NADP+)

释义

References

{{DISPLAYTITLE:15-hydroxyprostaglandin-I dehydrogenase (NADP⁺)}}{{enzyme
| Name = 15-hydroxyprostaglandin-I dehydrogenase (NADP⁺)
| EC_number = 1.1.1.231
| CAS_number = 79468-49-8
| IUBMB_EC_number = 1/1/1/231
| GO_code = 0047033
| image =
| width =
| caption =
}}

In enzymology, a 15-hydroxyprostaglandin-I dehydrogenase (NADP⁺) ({{EC number|1.1.1.231}}) is an enzyme that catalyzes the chemical reaction

(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13- dienoate + NADP⁺ (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH + H⁺

The 3 substrates of this enzyme are (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-, dienoate, and NADP⁺, whereas its 3 products are (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoa te:NADP⁺ 15-oxidoreductase. Other names in common use include prostacyclin dehydrogenase, PG I2 dehydrogenase, prostacyclin dehydrogenase, NADP⁺-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase, NADP⁺-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase, and 15-hydroxyprostaglandin-I dehydrogenase (NADP⁺).

References

{{cite journal |vauthors=Korff JM, Jarabak J | date = 1982 | title = Isolation and properties of an NADP⁺-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase from rabbit kidney | journal = Methods Enzymol. | volume = 86 | pages = 152–5 | pmid = 6182444 | doi = 10.1016/0076-6879(82)86185-5 }}

3 : EC 1.1.1|NADPH-dependent enzymes|Enzymes of unknown structure

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