| 词条 | Estradiol 3-propionate |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = [(8R,9S,13S,14S,17S)-17-Hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] propanoate | image = Estradiol 3-propionate.svg | width = 250px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = Intramuscular, vaginal[1] | class = Estrogen; Estrogen ester | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 6045-51-8 | CAS_supplemental = | ATC_prefix = None | ATC_suffix = | ATC_supplemental = | PubChem = | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 2298529 | UNII = DS9WS297BV | KEGG = | ChEBI = | ChEMBL = | synonyms = Estradiol 3-propanoate; 3-Propanoylestradiol; 3,17β-Hydroxyestra-1,3,5(10)-trien-3-yl propionate | C=21 | H=28 | O=3 | molecular_weight = 328.445 g/mol | SMILES = CCC(=O)Oc1ccc2c(c1)CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4O)C | StdInChI_Ref = | StdInChI = InChI=1S/C21H28O3/c1-3-20(23)24-14-5-7-15-13(12-14)4-6-17-16(15)10-11-21(2)18(17)8-9-19(21)22/h5,7,12,16-19,22H,3-4,6,8-11H2,1-2H3/t16-,17-,18+,19?,21?/m1/s1 | StdInChIKey_Ref = | StdInChIKey = InChIKey=FONFXFZWMZJFCD-NYKHLBABSA-N }}Estradiol 3-propionate, or 3-propanoylestradiol, also known as estra-1,3,5(10)-triene-3,17β-diol 3-propionate, is a semisynthetic, steroidal estrogen that was never marketed.[1][2] It is an estrogen ester, specifically, a propionic acid ester of estradiol, and acts as a prodrug to it in vivo.[1][2] The chemical structure of estradiol 3-propionate is contained within estradiol dipropionate, estrapronicate, and orestrate, all of which are also estradiol esters.[2] See also
References1. ^1 2 {{cite journal | vauthors = Woolfson AD, Elliott GR, Gilligan CA, Passmore CM | title = Design of an intravaginal ring for the controlled delivery of 17 beta-estradiol as its 3-acetate ester | journal = J Control Release | volume = 61 | issue = 3 | pages = 319–28 | year = 1999 | pmid = 10477804 | doi = | url = }} {{Estrogen receptor modulators}}{{Steroid-stub}}{{Genito-urinary-drug-stub}}2. ^1 2 {{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=RA1-PA129|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|page=898}} 5 : Abandoned drugs|Estradiol esters|Estranes|Propionate esters|Synthetic estrogens |
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