| 词条 | Estramustine |
| 释义 |
| Verifiedfields = verified | Watchedfields = verified | verifiedrevid = | IUPAC_name = [(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate | image = Estramustine.svg | alt = Skeletal formula of estramustine | width = 250px | image2 = Estramustine 3D ball.png | alt2 = Ball-and-stick model of the estramustine molecule | width2 = 250px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | class = Nitrogen mustard; Alkylating antineoplastic agent; Estrogen; Estrogen ester | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 2998-57-4 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 259331 | IUPHAR_ligand = | DrugBank_Ref = {{drugbankcite|changed|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 227635 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 35LT29625A | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D04066 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 4868 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 1575 | synonyms = EM; EaM; Leo 275; Ro 21-8837; Estradiol 3-(bis(2-chloroethyl)carbamate) ester; Estra-1,3,5(10)-triene-3,17β-diol 3-(bis(2-chloroethyl)carbamate) ester | C=23 | H=31 | Cl=2 | N=1 | O=3 | molecular_weight = 440.405 g/mol | SMILES = C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C23H31Cl2NO3/c1-23-9-8-18-17-5-3-16(29-22(28)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)27/h3,5,14,18-21,27H,2,4,6-13H2,1H3/t18-,19-,20+,21+,23+/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = FRPJXPJMRWBBIH-RBRWEJTLSA-N }}Estramustine ({{abbrlink|INN|International Nonproprietary Name}}, {{abbrlink|USAN|United States Adopted Name}}, {{abbrlink|BAN|British Approved Name}}) is a estrogen and cytostatic antineoplastic agent which was never marketed.[1][2] It is an estrogen ester – specifically, the C3 normustine ester of estradiol – and acts in part as a prodrug of estradiol in the body.[1][2] Estramustine phosphate, the C17β phosphate ester of estramustine and a prodrug of estramustine, estromustine, estradiol, and estrone, is marketed and used in the treatment of prostate cancer.[1][2] See also
References1. ^1 2 {{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA502|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=502–}} {{Estrogen receptor modulators}}{{Androgen receptor modulators}}{{Steroid-stub}}{{Antineoplastic-drug-stub}}2. ^1 2 {{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA406|date=January 2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=406–}} 15 : Abandoned drugs|Antiandrogens|Antigonadotropins|Antineoplastic drugs|Carbamates|Diols|Estradiol esters|Estranes|Estrogens|Hormonal antineoplastic drugs|Human drug metabolites|Mitotic inhibitors|Nitrogen mustards|Organochlorides|Chloroethyl compounds |
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