| 词条 | Ethylestradiol |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = (8R,9S,13S,14S,17S)-17-Ethyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol | image = 17-Ethylestradiol.svg | width = 225px | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | class = Estrogen | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 2553-34-6 | CAS_supplemental = | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 66428 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = | UNII = | KEGG = | ChEBI = | ChEMBL = 1627625 | synonyms = 17α-Ethylestradiol; 17α-Ethylestra-1,3,5(10)-triene-3,17β-diol | C=20 | H=28 | O=2 | molecular_weight = 300.442 g/mol | SMILES = CC[C@@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=C3C=CC(=C4)O)C)O | StdInChI_Ref = | StdInChI = 1S/C20H28O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h5,7,12,16-18,21-22H,3-4,6,8-11H2,1-2H3/t16-,17-,18+,19+,20+/m1/s1 | StdInChIKey_Ref = | StdInChIKey = GQHYKMYMSVJXJM-SLHNCBLASA-N }}Ethylestradiol, or 17α-ethylestradiol, also known as 17α-ethylestra-1,3,5(10)-triene-3,17β-diol, is a synthetic estrogen which was never marketed. It occurs as an active metabolite of the anabolic steroids norethandrolone and ethylestrenol formed via aromatase and is believed to be responsible for the estrogenic effects of norethandrolone and ethylestrenol.[1] The 3-methyl ether of ethylestradiol has been used as an intermediate in the synthesis of certain 19-nortestosterone anabolic steroids.[2][3][4] See also
References1. ^{{cite book|author=William Llewellyn|title=Anabolics|url=https://books.google.com/books?id=afKLA-6wW0oC&pg=PT330|year=2011|publisher=Molecular Nutrition Llc|isbn=978-0-9828280-1-4|pages=330–,591–598}} {{Estrogen receptor modulators}}{{Genito-urinary-drug-stub}}{{Steroid-stub}}2. ^{{cite journal|last1=Colton|first1=Frank B.|last2=Nysted|first2=Leonard N.|last3=Riegel|first3=Byron|last4=Raymond|first4=Albert L|title=17-Alkyl-19-nortestosterones|journal=Journal of the American Chemical Society|volume=79|issue=5|year=1957|pages=1123–1127|issn=0002-7863|doi=10.1021/ja01562a028}} 3. ^{{cite journal|last1=Fedorova|first1=O. I.|last2=Pekarskaya|first2=E. S.|last3=Lukashina|first3=I. V.|last4=Grinenko|first4=G. S.|title=Synthesis of some derivatives op 19-nortestosterone from estra-1,3,5(10)-trienes|journal=Pharmaceutical Chemistry Journal|volume=8|issue=8|year=1974|pages=462–465|issn=0091-150X|doi=10.1007/BF00757882}} 4. ^{{cite book|author=William Andrew Publishing|title=Pharmaceutical Manufacturing Encyclopedia|url=https://books.google.com/books?id=_J2ti4EkYpkC&pg=PA1513|date=22 October 2013|publisher=Elsevier|isbn=978-0-8155-1856-3|pages=1513–}} 5 : Abandoned drugs|Diols|Estranes|Human drug metabolites|Synthetic estrogens |
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