“16-alpha-hydroxysteroid dehydrogenase”的意思、由来-开放百科全书

词条

16-alpha-hydroxysteroid dehydrogenase

释义

References

{{enzyme
| Name = 16-alpha-hydroxysteroid dehydrogenase
| EC_number = 1.1.1.147
| CAS_number = 37250-74-1
| IUBMB_EC_number = 1/1/1/147
| GO_code = 0047005
| image =
| width =
| caption =
}}

In enzymology, a 16alpha-hydroxysteroid dehydrogenase ({{EC number|1.1.1.147}}) is an enzyme that catalyzes the chemical reaction

a 16alpha-hydroxysteroid + NAD(P)⁺ a 16-oxosteroid + NAD(P)H + H⁺

The 3 substrates of this enzyme are 16alpha-hydroxysteroid, NAD⁺, and NADP⁺, whereas its 4 products are 16-oxosteroid, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 16alpha-hydroxysteroid:NAD(P)⁺ 16-oxidoreductase. This enzyme is also called 16alpha-hydroxy steroid dehydrogenase.

References

{{cite journal |vauthors=Meigs RA, Ryan KJ | date = 1966 | title = 16-alpha-hydroxysteroid dehydrogenase of rat kidney. Purification, assay, and properties | journal = J. Biol. Chem. | volume = 241 | pages = 4011–5 | pmid = 4380686 | issue = 17 }}

4 : EC 1.1.1|NADPH-dependent enzymes|NADH-dependent enzymes|Enzymes of unknown structure

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