| 词条 | EVT-101 |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = 5-[3-(Difluoromethyl)-4-fluorophenyl]-3-[(2-methylimidazol-1-yl)methyl]pyridazine | image = EVT-101.svg | width = | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | class = NMDA receptor antagonist | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 627525-33-1 | CAS_supplemental = 1166398-51-1 1189088-41-2 ({{abbrlink|HCl|hydrochloride}}) | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 22240172 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 11255877 | UNII = 14DN1WB87S | KEGG = | ChEBI = | ChEMBL = 3545350 | synonyms = ENS-101 | C=16 | H=13 | F=3 | N=4 | molecular_weight = 318.303 g/mol | SMILES = CC1=NC=CN1CC2=NN=CC(=C2)C3=CC(=C(C=C3)F)C(F)F | StdInChI_Ref = | StdInChI = 1S/C16H13F3N4/c1-10-20-4-5-23(10)9-13-6-12(8-21-22-13)11-2-3-15(17)14(7-11)16(18)19/h2-8,16H,9H2,1H3 | StdInChIKey_Ref = | StdInChIKey = BOVUHBFXPNLTKF-UHFFFAOYSA-N }}EVT-101, also known as ENS-101, is an experimental medication which originated from Roche and is under development by Evotec AG for the treatment of major depressive disorder.[1] It acts as a selective NMDA receptor subunit 2B (NR2B) antagonist.[1][2] As of November 2017, EVT-101 is in phase II clinical trials for major depressive disorder, although no recent reports of development have been identified.[1] The drug was first claimed by Roche in 2002.[3] See also
References1. ^1 2 http://adisinsight.springer.com/drugs/800023880 2. ^https://www.evotec.com/uploads/media_library/14/AC_SfN_Poster_2010_FINAL.pdf 3. ^{{cite journal | vauthors = Santangelo RM, Acker TM, Zimmerman SS, Katzman BM, Strong KL, Traynelis SF, Liotta DC | title = Novel NMDA receptor modulators: an update | journal = Expert Opin Ther Pat | volume = 22 | issue = 11 | pages = 1337–52 | year = 2012 | pmid = 23009122 | pmc = 3677696 | doi = 10.1517/13543776.2012.728587 | url = }} External links
6 : Antidepressants|Experimental drugs|Imidazoles|NMDA receptor antagonists|Organofluorides|Pyridazines |
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