| 释义 |
- Function
- References
- Further reading
{{Orphan|date=August 2018}}{{Infobox_gene}}Fas associated factor family member 2 is a protein that in humans is encoded by the FAF2 gene. [1]FunctionThe protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008]. References 1. ^{{cite web| title = Entrez Gene: Fas associated factor family member 2| url = https://www.ncbi.nlm.nih.gov/gene/23197| accessdate = 2018-07-21}}
Further reading {{refbegin | 2}}- {{cite journal |vauthors=Imai Y, Nakada A, Hashida R, Sugita Y, Tanaka T, Tsujimoto G, Matsumoto K, Akasawa A, Saito H, Oshida T |title=Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue=5 |pages=1282–90 |date=October 2002 |pmid=12372427 |doi= |url=}}
- {{cite journal |vauthors=Phan VT, Ding VW, Li F, Chalkley RJ, Burlingame A, McCormick F |title=The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans |journal=Mol. Cell. Biol. |volume=30 |issue=9 |pages=2264–79 |date=May 2010 |pmid=20160012 |pmc=2863595 |doi=10.1128/MCB.01450-08 |url=}}
- {{cite journal |vauthors=Lee JN, Kim H, Yao H, Chen Y, Weng K, Ye J |title=Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=107 |issue=50 |pages=21424–9 |date=December 2010 |pmid=21115839 |pmc=3003070 |doi=10.1073/pnas.1011859107 |url=}}
- {{cite journal |vauthors=Suzuki M, Otsuka T, Ohsaki Y, Cheng J, Taniguchi T, Hashimoto H, Taniguchi H, Fujimoto T |title=Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets |journal=Mol. Biol. Cell |volume=23 |issue=5 |pages=800–10 |date=March 2012 |pmid=22238364 |pmc=3290640 |doi=10.1091/mbc.E11-11-0950 |url=}}
- {{cite journal |vauthors=Wang CW, Lee SC |title=The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis |journal=J. Cell Sci. |volume=125 |issue=Pt 12 |pages=2930–9 |date=June 2012 |pmid=22454508 |doi=10.1242/jcs.100230 |url=}}
- {{cite journal |vauthors=Olzmann JA, Richter CM, Kopito RR |title=Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=110 |issue=4 |pages=1345–50 |date=January 2013 |pmid=23297223 |pmc=3557085 |doi=10.1073/pnas.1213738110 |url=}}
- {{cite journal |vauthors=Kim H, Zhang H, Meng D, Russell G, Lee JN, Ye J |title=UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids |journal=J. Lipid Res. |volume=54 |issue=8 |pages=2144–52 |date=August 2013 |pmid=23720822 |pmc=3708364 |doi=10.1194/jlr.M037218 |url=}}
- {{cite journal |vauthors=Kim H, Ye J |title=Cellular responses to excess fatty acids: focus on ubiquitin regulatory X domain-containing protein 8 |journal=Curr. Opin. Lipidol. |volume=25 |issue=2 |pages=118–24 |date=April 2014 |pmid=24378746 |doi=10.1097/MOL.0000000000000048 |url=}}
- {{cite journal |vauthors=Schrul B, Kopito RR |title=Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains |journal=Nat. Cell Biol. |volume=18 |issue=7 |pages=740–51 |date=July 2016 |pmid=27295553 |pmc=4925261 |doi=10.1038/ncb3373 |url=}}
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