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词条 Fayaz A. Malik
释义

  1. Biography

  2. Awards and honors

  3. Selected bibliography

      Research Articles    Books/Chapters  

  4. See also

  5. Notes

  6. References

  7. External links

{{Infobox scientist
| name = Fayaz A. Malik
| image =
| alt =
| caption =
| birth_date =
| birth_place = India
| death_date =
| death_place =
| residence = Jammu & Kashmir, India
| nationality = Indian
| fields = {{ublist | Pharmacology | Cancer Stem Cell Biology }}
| workplaces = {{ublist | Indian Institute of Integrative Medicine }}
| alma_mater =
| doctoral_advisor =
| doctoral_students =
| known_for = Studies involve understanding the regulation of Cancer Stem Cells during tumor metastasis in Breast Cancer and discovery of new targets and target based therapeutic agents addressing drug resistant cancers.
| awards = {{ublist| 2009 CSIR Young Scientist of Year Award | 2014 N-BIOS Prize }}
}}Fayaz Ahmad Malik is an Indian pharmacologist, cancer biologist and a scientist at the Indian Institute of Integrative Medicine of the Council of Scientific and Industrial Research. He is known for his studies on investigating the regulatory mechanisms of Cancer Stem Cells during tumor metastasis. His studies also involve the identification of signalling networks conferring resistance to current anti-cancer therapies. His discovery of new anticancer agents holds a number of patents for the processes he has developed. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to Biosciences, in 2014.[1]

The Department of Science and Technology (DST) of the Government of India awarded him the Swaranajayanti Fellowship, one of the prestigious Fellowship awards, for his advanced research in cancer biology, in 2013-14.

Biography

Fayaz Malik, after securing a master's degree in biotechnology and a PhD,.[2] He started his career by joining the Indian Institute of Integrative Medicine of the Council of Scientific and Industrial Research where he is a senior scientist of the Cancer Research and Drug Discovery group.[3] His major research focus remains to understand the critical regulatory biological mechanisms predisposed to the failure of current therapies, acquired resistance, and the onset of metastasis by exploring cellular catabolic machinery and regulatory networks of Cancer Stem Cells in subtypes of breast cancer.[4] . He has also developed many processes for which he holds the patents.[5][6][7] His studies have been documented by way of a number of articles[8]{{Refn|group=note|Please see Selected bibliography section}} and Google Scholar, an online repository of scientific articles has listed 70 of them.[9] Besides, he has contributed chapters to books published by others.[10] He has also participated in various seminars and conferences to give invited speeches.[11][12]

Awards and honors

Malik received the Young Scientist of Year Award from the Council of Scientific and Industrial Research in 2009 and Youn Scientits Awards from Jammu and Kashmir Government in 2010 [13] The Department of Biotechnology (DBT) of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards in 2014.[14]

Selected bibliography

Research Articles

  • Korkaya H, Kim G, Davis A, Malik F, Henry N, Ithimakin S, Quraishi A, Tawakkol N, Chung S, Luther T, Paholak H, Liu S, Hassan K, Zen Q, Clouthier SG, Wicha M. Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population. Mol Cell. 2012 Aug 24; 47(4): 570–584.  https://dx.doi.org/10.1016%2Fj.molcel.2012.06.014
  • {{Cite journal |last=Kim |first=G |last2=Ouzounova |first2=M |last3=Quraishi |first3=A A |last4=Davis |first4=A |last5=Tawakkol |first5=N |last6=Clouthier |first6=S G |last7=Malik |first7=F |last8=Paulson |first8=A K |last9=D'Angelo |first9=R C |date=2014-02-17 |title=SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model |journal=Oncogene |language=En |volume=34 |issue=6 |pages=671–680 |doi=10.1038/onc.2014.4 |pmid=24531711|pmc=4285772 }}
  • Anup S Pathania, Santosh K Guru, Suresh Kumar, Ashok Kumar, Masroor Ahmad, Shashi Bhushan, Bhahwal A Shah, Amit Nargotra, Ram Vishwakarma, Hasan Korkaya, Fayaz Malik, Interplay between cell cycle and autophagy induced by boswellic acid analog Scientific Reports (2016): 6,33146 https://www.nature.com/articles/srep33146.ris
  • Ithimakin S#, Day K#, Malik F#, Zen Q, Dawsey J, Bersano-Begey F, Quraishi A, Davis A, Hall C, Palanisamy N, Clouthier SG, Day ML, Kleer CG, Thomas DG, Hayes DF, Korkaya H, Wicha MS HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: Implications for efficacy of adjuvant trastuzumab. Cancer Res. 2013 Mar 1;73(5):1635-46. https://doi.org/10.1158/0008-5472.CAN-12-3349
  • Anup S Pathania, Zahoor A Wani, Santosh K Guru, Suresh Kumar, Shashi Bhushan, Hasan Korkaya, Darren F Seals, Ajay Kumar, Dilip M Mondhe, Zabeer Ahmed, Bal K Chandan, Fayaz Malik, The anti-angiogenic and cytotoxic effects of the boswellic acid analog BA145 are potentiated by autophagy inhibitors Molecular Cancer (2015)14:6 https://doi.org/10.1186/1476-4598-14-6
  • B Wadhwa, U Makhdoomi, R Vishwakarma, F Malik Protein kinase B: emerging mechanisms of isoform-specific regulation of cellular signaling in cancer Anti-cancer drugs, (2017) 28 :569-580
  • S Kumar, SK Guru, AS Pathania, A Kumar, S Bhushan, F Malik Autophagy triggered by magnolol derivative negatively regulates angiogenesis. Cell Death & Disease 4,e889 (2013) https://www.nature.com/articles/cddis2013399.ris
  • {{Cite journal |last=Pathania |first=Anup Singh |last2=Guru |first2=Santosh Kumar |last3=Verma |first3=M.K. |last4=Sharma |first4=Chetna |last5=Abdullah |first5=Sheikh Tasduq |last6=Malik |first6=Fayaz |last7=Chandra |first7=Suresh |last8=Katoch |first8=Meenu |last9=Bhushan |first9=Shashi |date=2013 |title=Disruption of the PI3K/AKT/mTOR signaling cascade and induction of apoptosis in HL-60 cells by an essential oil from Monarda citriodora |journal=Food and Chemical Toxicology |volume=62 |pages=246–254 |doi=10.1016/j.fct.2013.08.037}}
  • Jia Ke, Zhiju Zhao, Su-Hyung Hong, Shoumin Bai, Zhen He, Fayaz Malik, Jiahui Xu, Lei Zhou, Weilong Chen, Rachel Martin-Trevino, Xiaojian Wu, Ping Lan, Yongju Yi, Christophe Ginestier, Ingrid Ibarra, Li Shang, Sean McDermott, Tahra Luther, Shawn G Clouthier, Max S Wicha, Suling Liu Role of microRNA221 in regulating normal mammary epithelial hierarchy and breast cancer stem-like cells Oncotarget. 2015 Feb; 6(6): 3709–3721 https://dx.doi.org/10.18632%2Foncotarget.2888
  • F Malik, H Korkaya, SG Clouthier, MS Wicha Breast Cancer Heterogeneity: Need to Review Current Treatment Strategies Current Breast Cancer Reports 4 (4), 225-23 https://link.springer.com/article/10.1007/s12609-012-0093-5#citeas
  • Santosh Kumar Guru, Anup Singh Pathania, Suresh Kumar, Manjeet Kumar, Satiander Rana, Ajay Kumar, Fayaz Malik, RA Vishwakarma, Shashi Bhushan Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade Cancer Res. 2015 Jul 15;75(14):2886-96.http://cancerres.aacrjournals.org/content/75/14/2886.short
  • {{Cite journal |last=Khajuria |first=Anamika |last2=Gupta |first2=Amit |last3=Singh |first3=Surjeet |last4=Malik |first4=Fayaz |last5=Singh |first5=Jaswant |last6=Suri |first6=K.A. |last7=Satti |first7=N.K. |last8=Qazi |first8=G.N. |last9=Srinivas |first9=V.K. |date=2007 |title=RLJ-NE-299A: A new plant based vaccine adjuvant |journal=Vaccine |volume=25 |issue=14 |pages=2706–2715 |doi=10.1016/j.vaccine.2006.06.036}}

Books/Chapters

  • Fayaz Malik, Hasan Korkaya, Shawn G Clouthier, Max S Wicha, Regulation of Breast Cancer Stem Cells by Mesenchymal Stem Cells in the Metastatic Niche (2015): 123, Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/9781118670613#page=130
  • Anup S Pathania, Ubaid S Makhdoomi, Fayaz A Malik Genetic and Epigenetic Regulation of Autophagy in Cancer Genome (2017):1-29, Analysis and Human Health, https://link.springer.com/chapter/10.1007/978-981-10-4298-0_1
  • Hasan Korkaya, Fayaz Malik, Breast Cancer Stem Cells: Responsible for Therapeutic Resistance and Relapse? Breast Cancer Metastasis and Drug Resistance, (2013):385-398 https://link.springer.com/chapter/10.1007/978-1-4614-5647-6_21
  • {{Cite book |title=Economic crisis in tea industry : strategies for scientific management |last= N. K. Jain, John Weisburger, Maqsood Siddiqi |last2=Jaswant Singh, Fayaz Malik Fayaz Malik Fayaz Malik and G. N. Qazi (Chapter authors) |date=2008 |publisher=Studium Press LLC |isbn=9781933699370 |location=Houston, Tex. |chapter=Protective role of tea against cancer and infectious diseases through immune activation }}

See also

{{Div col|colwidth=30em}}
  • Breast cancer
  • Monarda citriodora
{{Div col end}}{{portal|India|Biology|Medicine}}

Notes

1. ^{{Cite web |url=http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf |title=Awardees of National Bioscience Awards for Career Development |date=2016 |publisher=Department of Biotechnology |access-date=2017-11-20}}
2. ^{{Cite web |url=http://www.incredb.org/investigator.php?incredb_id=309 |title=Fayaz Ahmad Malik, Ph.D. profile in India Cancer Research Database |date=2018-05-14 |website=www.incredb.org |access-date=2018-05-14}}
3. ^{{Cite web |url=http://www.iiim.res.in/People/Scientific.php |title=Indian Institute of Integrative Medicine - List of scientists |date=2018-05-14 |website=www.iiim.res.in |access-date=2018-05-14}}
4. ^{{Cite web |url=http://www.incredb.org/cv/Dr.%20Fayaz%20malik.pdf |title=Scientist profile |date=2018-05-14 |website=Incredb |access-date=2018-05-14}}
5. ^{{Cite web |url=http://www.euindiacoop.org/2009/downloads/kazi.pdf |title=Traditional Knowledge Base For Drug Discovery |date=2018-05-14 |website=www.euindiacoop.org |access-date=2018-05-14}}
6. ^{{Cite web |url=https://patents.google.com/patent/WO2009122447A1/ru |title=Semi-synthetic sesquiterpene lactone parthenin compound useful for cytotoxicity against cancer cell lines and anticander agent |date=2018-05-14 |website=Google Patents |access-date=2018-05-14}}
7. ^{{Cite web |url=http://www.iiim.res.in/Research_achievements/representative-patents.php |title=Patents Granted in Foreign Countries |date=2018-05-14 |website=www.iiim.res.in |access-date=2018-05-14}}
8. ^{{Cite web |url=https://www.researchgate.net/profile/Fayaz_Malik |title=On ResearchGate |date=2018-05-13 |publisher=On ResearchGate |access-date=2018-05-13}}
9. ^{{Cite web |url=https://scholar.google.com/citations?user=-E9ppvMAAAAJ&hl=en |title=On Google Scholar |date=2018-05-13 |publisher=Google Scholar |access-date=2018-05-13}}
10. ^{{Cite book |url=https://www.worldcat.org/oclc/262700162 |title=Economic crisis in tea industry : strategies for scientific management |last= N. K. Jain, John Weisburger, Maqsood Siddiqi |last2=Jaswant Singh, Fayaz Malik Fayaz Malik Fayaz Malik and G. N. Qazi (Chapter authors) |date=2008 |publisher=Studium Press LLC |isbn=9781933699370 |location=Houston, Tex. |chapter=Protective role of tea against cancer and infectious diseases through immune activation |oclc=262700162}}
11. ^{{Cite web |url=http://v1.indiabioscience.org/content/attendees-0 |title=Attendees - indiabioscience.org |date=2018-05-14 |website=v1.indiabioscience.org |language=en |access-date=2018-05-14}}
12. ^{{Cite web |url=http://www.dailyexcelsior.com/seminar-recent-trends-genomics-metabolomics-concludes-ju/ |title=Seminar on "Recent Trends in Genomics and Metabolomics" concludes at JU |date=2018-05-14 |website=Daily Excelsior |access-date=2018-05-14}}
13. ^{{Cite web |url=http://www.csir.res.in/sites/default/files/yaward09_C.pdf |title=CSIR Young Scientists Awards 2009 |date=2009 |website=Council of Scientific and Industrial Research |access-date=2018-05-14}}
14. ^{{Cite web |url=http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf |title=Awardees of National Bioscience Awards for Career Development |date=2016 |publisher=Department of Biotechnology |access-date=2017-11-20}}

References

{{reflist|30em}}

External links

  • {{Cite web |url=https://www.youtube.com/watch?v=mGywsI6Cyw8 |title=Five year journey at CSIR-IIIM |last=Malik |first=Fayaz |date=October 26, 2015 |website=India BioScience |access-date=2018-05-14}}
{{N-BIOS Laureates 2010–2019}}{{authority control}}{{DEFAULTSORT:Malik, Fayaz A.}}

9 : N-BIOS Prize recipients|Indian scientific authors|Living people|Indian academics|Scientists from Jammu and Kashmir|Indian medical writers|Year of birth missing (living people)|Indian pharmacologists|Indian biochemists

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