| 词条 | 18F-EF5 |
| 释义 |
| Watchedfields = changed | verifiedrevid = 443718730 | ImageFile = EF5 structure.svg | ImageSize = 200px | ImageAlt = | IUPACName = 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide | OtherNames = NSC-684681; EF-5 |Section1={{Chembox Identifiers | CASNo = 152721-37-4 | CASNo_Ref = {{cascite|correct|CAS}} | PubChem = 389053 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 344807 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 383HJ2T87O | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = JGGDSDPOPRWSCX-UHFFFAOYSA-N | SMILES = O=[N+]([O-])c1nccn1CC(=O)NCC(F)(F)C(F)(F)F | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI=1S/C8H7F5N4O3/c9-7(10,8(11,12)13)4-15-5(18)3-16-2-1-14-6(16)17(19)20/h1-2H,3-4H2,(H,15,18) |Section2={{Chembox Properties | C=8 | H=7 | F=5 | N=4 | O=3 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }}EF5 is a nitroimidazole derivative used in oncology research.[1] Due to its similarity in chemical structure to etanidazole, EF5 binds in cells displaying hypoxia.[2] The 18F-radiolabeled derivative of EF5 is being studied for its possibility to be used in positron emission tomography (PET) to detect low levels of oxygen in brain tumors.[3] This can help show how a tumor will respond to treatment. References1. ^{{cite journal | doi = 10.1016/j.ijrobp.2005.05.068 |author1=Evans, Sydney M. |author2=Fraker, Douglas |author3=Hahn, Stephen M. |author4=Gleason, Kristen |author5=Jenkins, W. Timothy |author6=Jenkins, Kevin |author7=Hwang, Wei-Ting |author8=Zhang, Paul |author9=Mick, Rosemarie |author10=Koch, Cameron J | title = EF5 binding and clinical outcome in human soft tissue sarcomas | journal = International Journal of Radiation Oncology, Biology, Physics | year = 2006 | volume = 64 | issue = 3 | pages = 922–927}} 2. ^{{cite journal | title = Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts |author1=Lord, Edith M. |author2=Harwell, Lee |author3=Koch, Cameron J. | journal = Cancer Research | year = 1993 | volume = 53 | issue = 23 | pages = 5721–5726 | pmid = 8242628}} 3. ^{{cite journal | doi = 10.1007/s00259-002-1037-5 |author1=Ziemer, L. S. |author2=Evans, S. M. |author3=Kachur, A. V. |author4=Shuman, A. L. |author5=Cardi, C. A. |author6=Jenkins, W. T. |author7=Karp, J. S. |author8=Alavi, A. |author9=Dolbier, W. R. |author10=Koch, C. J. | title = Noninvasive imaging of tumor hypoxia in rats using the 2-nitroimidazole 18F-EF5 | journal = European Journal of Nuclear Medicine and Molecular Imaging | year = 2003 | volume = 30 | issue = 2 | pages = 259–266 | pmid = 12552344}} 1 : Nitroimidazoles |
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