| 词条 | Fertirelin |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide | image = Fertirelin.svg | width = 250px | tradename = Ovalyse | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | class = GnRH analogue; GnRH agonist; Antigonadotropin | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 38234-21-8 | CAS_supplemental = 66002-66-2 (acetate) | ATCvet = yes | ATC_prefix = H01 | ATC_suffix = CA91 | ATC_supplemental = | PubChem = 188304 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 163670 | UNII = JD54DU77I8 | KEGG = D07957 | ChEBI = | ChEMBL = 3272563 | synonyms = TAP-031; U-69689; 9-(N-Ethyl-L-prolinamide)-10-deglycinamide; 9-(N)-Et-ProNH2-10-des-GlyNH2-LHRH; Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-NHEt | C=55 | H=76 | N=16 | O=12 | molecular_weight = 1153.313 g/mol | SMILES = CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6 | StdInChI_Ref = | StdInChI = 1S/C55H76N16O12/c1-4-59-53(82)44-12-8-20-71(44)54(83)38(11-7-19-60-55(56)57)66-49(78)39(21-30(2)3)65-46(75)27-62-47(76)40(22-31-13-15-34(73)16-14-31)67-52(81)43(28-72)70-50(79)41(23-32-25-61-36-10-6-5-9-35(32)36)68-51(80)42(24-33-26-58-29-63-33)69-48(77)37-17-18-45(74)64-37/h5-6,9-10,13-16,25-26,29-30,37-44,61,72-73H,4,7-8,11-12,17-24,27-28H2,1-3H3,(H,58,63)(H,59,82)(H,62,76)(H,64,74)(H,65,75)(H,66,78)(H,67,81)(H,68,80)(H,69,77)(H,70,79)(H4,56,57,60)/t37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 | StdInChIKey_Ref = | StdInChIKey = DGCPIBPDYFLAAX-YTAGXALCSA-N }}Fertirelin, or fertirelin acetate, sold under the brand name Ovalyse, is a gonadotropin-releasing hormone agonist (GnRH agonist) which has been marketed in the United Kingdom and Austria.[1][2][3] It may no longer be available.[4] Fertirelin has been used in veterinary medicine.[2] It may have been used in the treatment of sex hormone-dependent conditions and infertility in women.[3] The drug was first introduced in 1981 in Japan to treat various kinds of ovarian failure in cattle.[5] Fertirelin is a synthetic peptide and GnRH analogue.[1][2] It is used as the acetate salt.[2] See also
References1. ^1 {{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA549|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=549–}} {{GnRH and gonadotropins}}{{GnRH and gonadotropin receptor modulators}}{{Genito-urinary-drug-stub}}2. ^1 2 3 {{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA441|year=2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=441–}} 3. ^1 {{cite book|author1=I.K. Morton|author2=Judith M. Hall|title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA120|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-011-4439-1|pages=120–}} 4. ^https://www.drugs.com/international/fertirelin.html 5. ^{{cite journal | vauthors = Okada J, Seo T, Kasahara F, Takeda K, Kondo S | title = New degradation product of des-Gly10-NH2-LH-RH-ethylamide (fertirelin) in aqueous solution | journal = J Pharm Sci | volume = 80 | issue = 2 | pages = 167–70 | year = 1991 | pmid = 2051323 | doi = | url = }} 3 : GnRH agonists|Peptides|Veterinary drugs |
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