| 词条 | Fluclotizolam |
| 释义 |
| IUPAC_name = 2-chloro-4-(2-fluorophenyl)-9-methyl-4H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepine | image = Fluclotizolam_structure.png | width = 200 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_UK = | legal_status = | routes_of_administration = | addiction_liability = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = | ATC_prefix = | ATC_suffix = | PubChem = 21317700 | ChemSpiderID = | C=15 | H=10 | Cl=1 | F=1 | N=4 | S=1 | melting_point = | smiles = Fc4ccccc4C2=NCc1nnc(C)n1c3sc(Cl)cc23 | StdInChI=1S/C15H10ClFN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)17)10-6-12(16)22-15(10)21(8)13/h2-6H,7H2,1H3 | StdInChIKey = ZDYRCUZZLRLMHG-UHFFFAOYSA-N }}Fluclotizolam is a thienotriazolodiazepine derivative which was first synthesised in 1979,[1] but was never marketed. It has subsequently been sold as a designer drug, first being definitively identified in 2017.[2][3][4] See also
References1. ^Hellerbach J, et al. Thienotriazolodiazepine derivatives. [https://patents.google.com/patent/US4155913A Patent US 4155913] {{Benzodiazepines}}{{Hypnotics and sedatives}}{{GABAAR PAMs}}2. ^Zawilska JB, Wojcieszak J. An expanding world of New Psychoactive Substances – Designer benzodiazepines. NeuroToxicology 2019 July; 73: 8-16. {{doi|10.1016/j.neuro.2019.02.015}} 3. ^Moosmann B., Auwärter V. (2018) Designer Benzodiazepines: Another Class of New Psychoactive Substances. In: Maurer H., Brandt S. (eds) New Psychoactive Substances. Handbook of Experimental Pharmacology, vol 252. {{doi|10.1007/164_2018_154}} 4. ^Chetraru E, Ameline A, Gheddar L, Raul JS, Kintz P. Les designer benzodiazepines: qu’en sait-on aujourd’hui?. Toxicologie Analytique et Clinique. 2018 Feb 1;30(1):5-18. {{doi|10.1016/j.toxac.2017.12.001}} 4 : Benzodiazepines|Designer drugs|GABAA receptor positive allosteric modulators|Thienotriazolodiazepines |
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