| 词条 | FolE RNA motif |
| 释义 |
| Name = folE | image = RF02977.svg | width = | caption = Consensus secondary structure and sequence conservation of folE RNA | Symbol = folE | AltSymbols = | Rfam = RF02977 | miRBase = | miRBase_family = | RNA_type = Cis-reg | Tax_domain = | GO = | SO = {{SO|0005836}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }}{{DISPLAYTITLE:folE RNA motif}} The folE RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] folE motifs are found in Alphaproteobacteria. folE motif RNAs likely function as cis-regulatory elements, in view of their positions upstream of protein-coding genes. Instances of the folE RNA motif are often located nearby to the predicted Shine-Dalgarno sequence of the downstream gene. This arrangement is consistent with a model of cis-regulation where the RNA allosterically controls access to the Shine-Dalgarno sequence, thus regulating the gene translationally. All known folE RNAs are present upstream of genes encoding GTP cyclohydrolase I, which performs a step in folate metabolism. The precise function of folE RNAs is not yet known, as of 2018. References1. ^{{cite journal |vauthors=Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR |title=Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions |journal=Nucleic Acids Res. |volume=45 |issue=18 |pages=10811-10823 |date=October 2017 |pmid=28977401 |pmc=5737381 |doi=10.1093/nar/gkx699 |url=}} 1 : Non-coding RNA |
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