Frederick Willis may refer to:

• Frederick Willis (American politician) (1904–1971), American politician in the Massachusetts House of Representatives
• Frederick Willis (rugby league), Welsh rugby league footballer of the 1920s
• Frederick Willis (British Army officer) (1823–1899), British Army general
• Frederick Smythe Willis (1866–1910), British-born Australian municipal official; mayor of Willoughby, New South Wales
• Frederick Willis (civil servant) (1863–1946), English lawyer and civil servant
• Fred Willis (born 1947), American football running back

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