| 词条 | FTHFS RNA motif |
| 释义 |
| Name = FTHFS | image = RF02981.svg | width = | caption = Consensus secondary structure and sequence conservation of FTHFS RNA | Symbol = FTHFS | AltSymbols = | Rfam = RF02981 | miRBase = | miRBase_family = | RNA_type = Cis-reg | Tax_domain = | GO = | SO = {{SO|0005836}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} The FTHFS RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] FTHFS motifs are found in metagenomic sequences derived from samples of the human gut. FTHFS motif RNAs likely function as cis-regulatory elements, in view of their positions upstream of protein-coding genes. FTHFS RNAs are consistently located upstream of genes encoding formate-tetrahydrofolate ligase, which produces 10-formyltetrahydrofolate. Such genes are also very commonly regulated by the previously established ZMP/ZTP riboswitch. These ZMP/ZTP-sensing riboswitches detect a shortage of formyltetrahydrofolate by measuring the levels of ZMP and or its triphosphorylated form ZTP; because formyltetrahydrofolate is heavily used in the de novo purine synthesis pathway, formyltetrahydrofolate starvation leads to a buildup of the purine intermediate ZMP, or the result of its triphosphorylation, ZTP. It was, however, noted[1] that the secondary structure of the FTHFS motif is simpler than many riboswitches, and it is less clear if this motif represents a promising riboswitch candidate. References1. ^1 {{cite journal |vauthors=Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR |title=Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions |journal=Nucleic Acids Res. |volume=45 |issue=18 |pages=10811-10823 |date=October 2017 |pmid=28977401 |pmc=5737381 |doi=10.1093/nar/gkx699 |url=}} 1 : Non-coding RNA |
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