| 词条 | GA-cis RNA motif |
| 释义 |
| Name = GA-cis | image = RF02987.svg | width = | caption = Consensus secondary structure and sequence conservation of GA-cis RNA | Symbol = GA-cis | AltSymbols = | Rfam = RF02987 | miRBase = | miRBase_family = | RNA_type = Gene; sRNA | Tax_domain = | GO = | SO = {{SO|0001263}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }}{{DISPLAYTITLE:GA-cis RNA motif}} The GA-cis RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] GA-cis motif RNAs are found in one species classified within the phylum Firmicutes: specifically, there are 9 predicted copies in Coprocuccus eutactus ATCC 27759. GA-cis RNAs are generally located in the 5' untranslated regions of protein-coding genes. Indeed, the RNAs are upstream of multiple genes that encode non-homologous proteins. If all examples of the RNA were upstream of homologous genes, there is the possibility that the RNAs were conserved in that position simply by inheritance. The non-homology of the genes downstream of COG2908 RNAs makes this scenario less likely. This evidence suggests that GA-cis RNAs function as cis-regulatory elements. However, due to some cases where a GA-cis RNA is not immediately upstream of a gene makes this hypothesis tentative. The GA-cis RNA motif is named because of the frequent occurrence of conserved GpA di-nucleotides in its sequence, and its locations that are typical of cis-regulatory elements. References1. ^{{cite journal |vauthors=Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR |title=Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions |journal=Nucleic Acids Res. |volume=45 |issue=18 |pages=10811-10823 |date=October 2017 |pmid=28977401 |pmc=5737381 |doi=10.1093/nar/gkx699 |url=}} 1 : Non-coding RNA |
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