Game chicken or Game Chicken may refer to:

• The Gamecock or game fowl, chickens bred for cockfighting
• A Game Chicken, a lost silent film from 1922
• Hen Pearce (1777–1809), English bare-knuckle prizefighter

• Serum Total Protein
• Serum total protein
• Serum trypsin inhibitor
• Ser (unit)
• Serupepeli Naqase
• Serusophone
• Seruvalsar Lake
• Seru (woreda)
• Serv
• Servaea
• Servais
• Servais Knaven
• Servais knaven
• Servais Le Roy
• Servais Prize
• Servais Prize for Literature
• Servais (saint)
• Servaline genet
• Servamox
• Servando Bayo
• Servando Canales International Airport
• Servando Teresa de Mier
• Servandus and Cermanus
• Servandus and Germanus
• Servant (CORBA)