| 词条 | Genome Project-Write |
| 释义 |
The Genome Project - Write (also known as GP-Write) includes sub-projects like Human Genome Project-Write (HGP-Write), formally announced on 2 Jun 2016, is an extension of Genome Projects (aimed at reading genomes since 1984), now to include development of technologies for synthesis and testing of many genomes of microbes, plants and animals.[1][2][3][4][5][6] This leverages two decades of work on Synthetic Biology and Artificial gene synthesis. The newly created GP-Write project will be managed by the Center of Excellence for Engineering Biology,[7] a new nonprofit organization. The researchers expect that the ability to synthesize large portions of many genomes would result in many scientific and medical advances.[1][2][3][4][5][6] Microbial Genome Projects - WriteTechnologies for constructing and testing Yeast artificial chromosomes, synthetic yeast genomes (Sc2.0)[8] and virus/phage-resistant bacterial genomes have industrial, agricultural and medical applications.[2] Human Genome Project-WriteThe human genome consists of three billion DNA nucleotides, which have been described in the Human Genome Project - Read program, 95% completed in 2004. Examples of goals of GP-Write include making cell lines that are resistant to all viruses and synthesis assembly lines to test variants of unknown significance that arise in research and diagnostic sequencing of human genomes (which has been exponentially improving in cost, quality and interpretation).[2] See also{{div col|colwidth=30em}}
References1. ^1 {{cite news |last=Pollack |first=Andrew |title=Scientists Announce HGP-Write, Project to Synthesize the Human Genome |url=https://www.nytimes.com/2016/06/03/science/human-genome-project-write-synthetic-dna.html |date=2 June 2016 |work=New York Times |accessdate=2 June 2016 }} 2. ^1 2 3 {{cite journal |author=Boeke, JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R, Chakravarti A, Cornish VW, Holt L, Isaacs FJ, Kuiken T, Lajoie M, Lessor T, Lunshof J, Maurano MT, Mitchell LA, Rine J, Rosser S, Sanjana NE, Silver PA, Valle D, Wang H, Way JC, Yang L | title=The Genome Project–Write |url=http://science.sciencemag.org/content/early/2016/06/01/science.aaf6850.full |date=2 June 2016 |journal=Science |doi=10.1126/science.aaf6850 |accessdate=2 June 2016 |display-authors=etal |volume=353 |pages=126–127 |pmid=27256881|bibcode=2016Sci...353..126B }} 3. ^1 {{cite news |last=Callaway |first=Ewen |title=Plan to Synthesize Human Genome Triggers a Mixed Response |url=http://www.scientificamerican.com/article/plan-to-synthesize-human-genome-triggers-a-mixed-response/ |date=2 June 2016 |work=Scientific American |accessdate=2 June 2016 }} 4. ^1 {{cite news |last=Regalado |first=Antonio |title=Plan to Fabricate a Genome Raises Questions on Designer Humans |url=https://www.technologyreview.com/s/601610/plan-to-fabricate-a-genome-raises-questions-on-designer-humans/ |date=2 June 2016 |work=MIT Technology Review |accessdate=2 June 2016 }} 5. ^1 {{cite news |last=Akst |first=Jef |title="Human Genome Project-Write" Unveiled |url=http://www.the-scientist.com/?articles.view/articleNo/46237/title/-Human-Genome-Project-Write--Unveiled/ |date=2 June 2016 |work=The Scientist |accessdate=2 June 2016 }} 6. ^1 {{Cite web|url=http://time.com/4356581/synthetic-human-genome/|title=The Brave New World of the Synthetic Human Genome|last=Opal|first=Puneet|last2=Kini|first2=Ameet|date=3 June 2016|work=Time|access-date=12 June 2016}} 7. ^{{cite web | title= Center of Excellence for Engineering Biology | url=http://engineeringbiologycenter.org/ | accessdate= 2 Mar 2017}} 8. ^{{cite web | title=Synthetic yeast genomes (Sc2.0) | accessdate= 2 Mar 2017 | url= http://syntheticyeast.org/}} Further reading
5 : Biotechnology|Genome projects|Human genome projects|Human Genome Project scientists|Life sciences industry |
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