请输入您要查询的百科知识：

　

词条 Genomic control
释义

  1. References

Genomic control (GC) is a statistical method that is commonly used to control for the confounding effects of population stratification in genetic association studies. The method was originally outlined by Bernie Devlin and Kathryn Roeder in a 1999 paper.[1] It involves using a set of anonymous genetic markers to estimate the effect of population structure on the distribution of the chi-square statistic. The distribution of the chi-square statistics for a given allele that is suspected to be associated with a given trait can then be compared to the distribution of the same statistics for an allele that is expected not to be related to the trait.[2][3] The method is supposed to involve the use of markers that are not linked to the marker being tested for a possible association.[4] In theory, it takes advantage of the tendency of population structure to cause overdispersion of test statistics in association analyses.[5] The genomic control method is as robust as family-based designs, despite being applied to population-based data.[6] It has the potential to lead to a decrease in statistical power to detect a true association, and it may also fail to completely eliminate the biasing effects of population stratification.[7] A more robust form of the genomic control method can be performed by expressing the association being studied as two Cochran–Armitage trend tests, and then applying the method to each test separately.[8]

References

1. ^{{Cite journal |last=Devlin |first=Bernie |author-link=Bernie Devlin |last2=Roeder |first2=Kathryn |author-link2=Kathryn Roeder |date=1999 |title=Genomic Control for Association Studies |journal=Biometrics |language=en |volume=55 |issue=4 |pages=997–1004 |doi=10.1111/j.0006-341X.1999.00997.x |issn=1541-0420|citeseerx=10.1.1.420.1751 }}
2. ^{{Cite journal |last=Donnelly |first=Peter |author-link=Peter Donnelly |last2=Phillips |first2=Michael S. |last3=Cardon |first3=Lon R. |last4=Marchini |first4=Jonathan |author-link4=Jonathan Marchini |date=May 2004 |title=The effects of human population structure on large genetic association studies |url=https://www.nature.com/articles/ng1337 |journal=Nature Genetics |language=en |volume=36 |issue=5 |pages=512–517 |doi=10.1038/ng1337 |pmid=15052271 |issn=1546-1718}}
3. ^{{Cite journal |last=Altshuler |first=David |author-link=David Altshuler |last2=Hirschhorn |first2=Joel N. |author-link2=Joel N. Hirschhorn |last3=Henderson |first3=Brian |last4=Sklar |first4=Pamela |author-link4=Pamela Sklar |last5=Lander |first5=Eric S. |author-link5=Eric Lander |last6=Kolonel |first6=Laurence N. |last7=Petryshen |first7=Tracey L. |last8=Pato |first8=Michele T. |last9=Pato |first9=Carlos N. |date=April 2004 |title=Assessing the impact of population stratification on genetic association studies |url=https://www.nature.com/articles/ng1333 |journal=Nature Genetics |language=en |volume=36 |issue=4 |pages=388–393 |doi=10.1038/ng1333 |pmid=15052270 |issn=1546-1718}}
4. ^{{Cite journal |last=Krawczak |first=Michael |last2=Dempfle |first2=Astrid |last3=Lieb |first3=Wolfgang |last4=Freitag-Wolf |first4=Sandra |last5=Yadav |first5=Pankaj |date=2015-10-01 |title=Allowing for population stratification in case-only studies of gene–environment interaction, using genomic control |journal=Human Genetics |language=en |volume=134 |issue=10 |pages=1117–1125 |doi=10.1007/s00439-015-1593-y |pmid=26297539 |issn=1432-1203}}
5. ^{{Cite journal |last=Devlin |first=Bernie |last2=Roeder |first2=Kathryn |last3=Wasserman |first3=Larry |author-link3=Larry A. Wasserman |date=2001-11-01 |title=Genomic Control, a New Approach to Genetic-Based Association Studies |url=https://www.sciencedirect.com/science/article/pii/S0040580901915424 |journal=Theoretical Population Biology |language=en |volume=60 |issue=3 |pages=155–166 |doi=10.1006/tpbi.2001.1542 |pmid=11855950 |issn=0040-5809}}
6. ^{{Cite journal |last=Roeder |first=Kathryn |last2=Devlin |first2=B. |last3=Bacanu |first3=Silviu-Alin |date=2000-06-01 |title=The Power of Genomic Control |url=https://www.cell.com/ajhg/abstract/S0002-9297(07)63545-9 |journal=The American Journal of Human Genetics |language=English |volume=66 |issue=6 |pages=1933–1944 |doi=10.1086/302929 |issn=1537-6605 |pmc=1378064 |pmid=10801388}}
7. ^{{Cite journal |last=Greenberg |first=David A. |last2=Zhang |first2=Junying |last3=Shmulewitz |first3=Dvora |date=2004 |title=Case-Control Association Studies in Mixed Populations: Correcting Using Genomic Control |url=https://www.karger.com/Article/FullText/83541 |journal=Human Heredity |language=english |volume=58 |issue=3–4 |pages=145–153 |doi=10.1159/000083541 |issn=1423-0062 |pmid=15812171}}
8. ^{{Cite journal |last=Gastwirth |first=Joseph L. |last2=Freidlin |first2=Boris |last3=Zheng |first3=Gang |date=2006-02-01 |title=Robust Genomic Control for Association Studies |url=https://www.cell.com/ajhg/abstract/S0002-9297(07)62366-0 |journal=The American Journal of Human Genetics |language=English |volume=78 |issue=2 |pages=350–356 |doi=10.1086/500054 |issn=1537-6605 |pmc=1380242 |pmid=16400614}}
{{Genetics-stub}}

2 : Statistical genetics|Statistical methods
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/9/27 7:25:24