| 词条 | Glesatinib |
| 释义 |
| IUPAC_name = N-[(3-Fluoro-4- | image = Glesatinib skeletal.svg | alt = | caption = | pronounce = | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = | pregnancy_category= | routes_of_administration = By mouth | legal_AU = | legal_AU_comment = | legal_CA = | legal_DE = | legal_NZ = | legal_UK = | legal_US = | legal_UN = | legal_status = Investigational | bioavailability = | protein_bound = | metabolism = | metabolites = | onset = | elimination_half-life = | duration_of_action = | excretion = | CAS_number = 936694-12-1 | class = | ATCvet = | ATC_prefix = None | ATC_suffix = | PubChem = 25181472 | DrugBank = | ChemSpiderID = 52084900 | UNII = 7Q29OXD98N | KEGG = D11136 | chemical_formula = | C=31 | H=27 | F=2 | N=5 | O=3 | S=2 | molecular_weight = | smiles = COCCNCc1ccc(nc1)c2cc3c(s2)c(ccn3)Oc4ccc(cc4F)NC(=S)NC(=O)Cc5ccc(cc5)F | StdInChI=1S/C31H27F2N5O3S2/c1-40-13-12-34-17-20-4-8-24(36-18-20)28-16-25-30(43-28)27(10-11-35-25)41-26-9-7-22(15-23(26)33)37-31(42)38-29(39)14-19-2-5-21(32)6-3-19/h2-11,15-16,18,34H,12-14,17H2,1H3,(H2,37,38,39,42) | StdInChIKey = YRCHYHRCBXNYNU-UHFFFAOYSA-N }}Glesatinib (MGCD265) is an experimental anti-cancer drug.[1] It is in phase 2 clinical trials for non-small cell lung cancer (NSCLC).[2] It is a spectrum selective tyrosine[1] kinase inhibitor "for the treatment of non-small cell lung cancer (NSCLC) patients with genetic alterations of MET".[3] References1. ^1 [https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=597305 glesatinib@cancer.gov] 2. ^[https://clinicaltrials.gov/ct2/show/NCT02954991 Phase 2 Study of Glesatinib, Sitravatinib or Mocetinostat in Combination With Nivolumab in Non-Small Cell Lung Cancer] 3. ^Mirati Therapeutics Provides Update On Glesatinib And Sitravatinib Clinical Trials And Pipeline Programs. Jan 2017 External links
5 : Tyrosine kinase inhibitors|Acetamides|Thioureas|Fluoroarenes|Experimental cancer drugs |
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