| 词条 | Gluconate-proton symporter |
| 释义 |
| Symbol =GntP | Name =Gluconate:H+ Symporter | image = | width = | caption = | Pfam =PF02447 | Pfam_clan = | InterPro =IPR003474 | SMART = | PROSITE = | SCOP = | TcdB = 2.A.8 | OPM family = | OPM protein = | PDB = }} The gluconate:H+ symporter (GntP) family (TC# 2.A.8) is a family of transport proteins belonging to the ion transporter (IT) superfamily.[1] Members of the GntP family include known gluconate permeases of E. coli and Bacillus species such as the D-Gluconate:H+ symporter of Bacillus subtillus (GntP; TC# 2.A.8.1.1) and the D-fructuronate/D-gluconate:H+ symporter of E. coli (GntP; TC# 2.A.8.1.3).[2][3][4] A representative list of proteins belonging to the GntP family can be found in the Transporter Classification Database.[5] StructureBioinformatic analysis suggests these proteins are of about 450 residues and possess 12 or 14 putative transmembrane α-helical spanners. No crystal structure data are available for GntP proteins as of early 2016. FunctionFour of the seven E. coli paralogues have been found to possess active gluconate uptake activity, and one of them (GntW; TC# 2.A.8.1.2) can accommodate both L-idonate and D-gluconate, although L-idonate is the physiological substrate. Another (GntP) transports D-gluconate with high affinity but is specifically induced by and transports D-fructuronate.[4] GntT of E. coli is the physiological gluconate permease.[6] Transport reactionThe generalized transport reaction catalyzed by proteins of the GntP family is: Carbohydrate acid (out) + nH+ (out) → Carbohydrate acid (in) + nH+ (in) References1. ^{{cite journal | vauthors = Prakash S, Cooper G, Singhi S, Saier MH | title = The ion transporter superfamily | journal = Biochimica et Biophysica Acta | volume = 1618 | issue = 1 | pages = 79–92 | date = December 2003 | pmid = 14643936 | doi = 10.1016/j.bbamem.2003.10.010 }} {{Portal bar|Molecular and Cellular Biology|border=no}}{{Dual|sourcepath=http://www.tcdb.org/search/result.php?tc=2.A.8|sourcearticle=The Gluconate:H+ Symporter (GntP) Family|source=Transporter Classification Database|date=9 March 2016}}{{membrane-protein-stub}}2. ^{{cite journal | vauthors = Peekhaus N, Tong S, Reizer J, Saier MH, Murray E, Conway T | title = Characterization of a novel transporter family that includes multiple Escherichia coli gluconate transporters and their homologues | journal = FEMS Microbiology Letters | volume = 147 | issue = 2 | pages = 233–8 | date = February 1997 | pmid = 9119199 | doi = 10.1016/s0378-1097(96)00532-0 }} 3. ^{{cite journal | vauthors = Reizer A, Deutscher J, Saier MH, Reizer J | title = Analysis of the gluconate (gnt) operon of Bacillus subtilis | journal = Molecular Microbiology | volume = 5 | issue = 5 | pages = 1081–9 | date = May 1991 | pmid = 1659648 | doi = 10.1111/j.1365-2958.1991.tb01880.x }} 4. ^1 {{cite journal | vauthors = Bates Utz C, Nguyen AB, Smalley DJ, Anderson AB, Conway T | title = GntP is the Escherichia coli Fructuronic acid transporter and belongs to the UxuR regulon | journal = Journal of Bacteriology | volume = 186 | issue = 22 | pages = 7690–6 | date = November 2004 | pmid = 15516583 | pmc = 524916 | doi = 10.1128/JB.186.22.7690-7696.2004 }} 5. ^{{Cite web|url=http://www.tcdb.org/search/result.php?tc=2.A.8|title=2.A.8 The Gluconate:H+ Symporter (GntP) Family|website=Transporter Classification Database|access-date=2016-03-04}} 6. ^{{cite journal | vauthors = Porco A, Peekhaus N, Bausch C, Tong S, Isturiz T, Conway T | title = Molecular genetic characterization of the Escherichia coli gntT gene of GntI, the main system for gluconate metabolism | journal = Journal of Bacteriology | volume = 179 | issue = 5 | pages = 1584–90 | date = March 1997 | pmid = 9045817 | pmc = 178870 }} 2 : Protein families|Solute carrier family |
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