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词条 Glycerol 2-phosphate
释义

  1. Applications

  2. Notes

{{Chembox
| Name = Glycerol 2-phosphate
| ImageFile = Glycerol 2-phosphate.svg
| ImageSize = 200px
| IUPACName = 1,3-Dihydroxypropan-2-yl dihydrogen phosphate
| OtherNames = 1,2,3-Propanetriol, 2-(dihydrogen phosphate)
Glycerol 2-phosphate
β-Glycerophosphate
β-Phosphoglycerol
BGP
| Section1 = {{Chembox Identifiers
| CASNo = 17181-54-3
| PubChem = 2526
| EC_number = 241-228-2
| UNII = WWH06G87W6
| ChEMBL = 1232903
| ChemSpiderID = 2431
| ChEBI = 17270
| KEGG = C02979
| DrugBank = DB01779
| StdInChI=1S/C3H9O6P/c4-1-3(2-5)9-10(6,7)8/h3-5H,1-2H2,(H2,6,7,8)
| StdInChIKey = DHCLVCXQIBBOPH-UHFFFAOYSA-N
| SMILES = C(C(CO)OP(=O)(O)O)O
| MeSHName = Beta-glycerophosphoric+acid
| Section2 = {{Chembox Properties
| C=3|H=9|O=6|P=1
| Appearance =
| Density =
| MeltingPt =
| BoilingPt =
| Section9 = {{Chembox Related
| OtherFunction = Glycerol 1-phosphate
Glycerol 3-phosphate
| OtherFunction_label = organophosphates
}}

Glycerol 2-phosphate is a phosphoric ester of glycerol. It is more commonly known as β-glycerophosphate or BGP.

Applications

β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor. It is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition.[1][2]

β-Glycerophosphate is also used to drive osteogenic differentiation of bone marrow stem cells in vitro.[3]

β-Glycerophosphate is used to buffer M17 media for Lactococcus culture in recombinant protein expression.[4]

Notes

1. ^{{cite web|publisher=Sigma-Aldrich|title=β-Glycerophosphate disodium salt hydrate|url=https://www.sigmaaldrich.com/catalog/product/sigma/g6376|accessdate=2018-05-30}}
2. ^{{cite web|publisher=Thermo Fisher Scientific|title=Protease and Phosphatase Inhibitors|url=https://www.thermofisher.com/us/en/home/life-science/protein-biology/protein-biology-learning-center/protein-biology-resource-library/pierce-protein-methods/protease-phosphatase-inhibitors.html|accessdate=2018-05-30}}
3. ^{{cite journal|author=Langenbach & Handschel|year=2013|title=Effects of dexamethasone, ascorbic acid and β-glycerophosphate on the osteogenic differentiation of stem cells in vitro|journal=Stem Cell Research & Therapy|volume=4|issue=5|pages=117|url=https://stemcellres.biomedcentral.com/articles/10.1186/scrt328|doi=10.1186/scrt328|pmid=24073831|pmc=3854789}}
4. ^{{cite journal|author=Terzaghi & Sandine|year=1975|title=Improved medium for lactic streptococci and their bacteriophages|journal=Applied Microbiology|volume=29|issue=6|pages=807–813|url=http://aem.asm.org/content/29/6/807.short|pmid=16350018|pmc=187084}}
{{Biochem-stub}}

1 : Organophosphates

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