| 词条 | GPAT4 |
| 释义 |
FunctionGPAT4 is involved in the biosynthesis of triglycerides.[2] The majority of triglycerides are synthesised from glycerol 3-phosphate (G3P) via the addition of three fatty acyl-CoA substrates, which are made from fatty acids. The first of these additions is catalysed by G3P acyltransferases (GPATs: EC 2.3.1.15), including GPAT4, yielding lysophosphatidic acid.[3] GPAT4 has been shown to be important for lactation, with QTL for several milk production and composition traits observed at this locus in cattle.[4] References1. ^{{cite web| title = Entrez Gene: Glycerol-3-phosphate acyltransferase 4| url = https://www.ncbi.nlm.nih.gov/gene/137964| accessdate = 2018-10-10}} 2. ^{{cite journal | vauthors = Coleman RA, Lee DP | title = Enzymes of triacylglycerol synthesis and their regulation | journal = Progress in Lipid Research | volume = 43 | issue = 2 | pages = 134–76 | date = March 2004 | pmid = 14654091 | doi = 10.1016/S0163-7827(03)00051-1 }} 3. ^{{cite journal | vauthors = Chen YQ, Kuo MS, Li S, Bui HH, Peake DA, Sanders PE, Thibodeaux SJ, Chu S, Qian YW, Zhao Y, Bredt DS, Moller DE, Konrad RJ, Beigneux AP, Young SG, Cao G | title = AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase | journal = Journal of Biological Chemistry | volume = 283 | issue = 15 | pages = 10048–57 | date = April 2008 | pmid = 18238778 | pmc = 2442282 | doi = 10.1074/jbc.M708151200 }} 4. ^{{cite journal | vauthors = Littlejohn MD, Tiplady K, Lopdell T, Law TA, Scott A, Harland C, Sherlock R, Henty K, Obolonkin V, Lehnert K, Macgibbon A, Spelman RJ, Davis SR, Snell RG | title = Expression Variants of the Lipogenic AGPAT6 Gene Affect Diverse Milk Composition Phenotypes in Bos taurus | journal = PLoS One | volume = 9 | issue = 1 | pages = e85757 | date = January 2014 | pmid = 24465687 | pmc = 3897493 | doi = 10.1371/journal.pone.0085757 }} Further reading{{refbegin | 2}}
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