Harry Isaacs may refer to:

• Harry Isaacs (pianist) (1902–1972), British pianist
• Harry Z. Isaacs (1904–1990), American racehorse owner
• Harry Isaacs (boxer) (1908–1961), South African boxer who competed in the 1928 Summer Olympics in Amsterdam
• Harry Isaacs (1893–1958), British Jewish boxer who fought under the name Harry Reeve

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