| 词条 | Hatchet ribozyme |
| 释义 |
The hatchet ribozyme is an RNA structure that catalyzes its own cleavage at a specific site. In other words, it is a self-cleaving ribozyme. Hatchet ribozymes were discovered by a bioinformatics strategy [1] as RNAs Associated with Genes Associated with Twister and Hammerhead ribozymes, or RAGATH. Subsequent biochemical analysis supports the conclusion of a ribozyme function, and determined further characteristics of the chemical reaction catalyzed by the ribozyme.[2] References1. ^{{cite journal |vauthors=Weinberg Z, Kim PB, Chen TH, Li S, Harris KA, Lünse CE, Breaker RR |title=New classes of self-cleaving ribozymes revealed by comparative genomics analysis |journal=Nat. Chem. Biol. |volume=11 |issue=8 |pages=606–10 |year=2015 |pmid=26167874 |pmc=4509812 |doi=10.1038/nchembio.1846 |url=}} 2. ^{{cite journal |vauthors=Li S, Lünse CE, Harris KA, Breaker RR |title=Biochemical analysis of hatchet self-cleaving ribozymes |journal=RNA |volume=21 |issue=11 |pages=1845–51 |year=2015 |pmid=26385510 |pmc=4604424 |doi=10.1261/rna.052522.115 |url=}} 2 : RNA|Ribozymes |
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