| 词条 | HHV-8-associated MCD |
| 释义 |
| name = HHV-8-associated MCD | synonyms = Giant lymph node hyperplasia, lymphoid hamartoma, angiofollicular lymph node hyperplasia | image = | width = | alt = | caption = | pronounce = | field = | specialty = Hematology, immunology, infectious disease, pathology | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = Based on patient history, physical exam, laboratory testing, medical imaging, histopathology | differential = | prevention = | treatment = | medication = | prognosis = | frequency = Approximately 300 new cases per year in the United States | deaths = }} Human herpesvirus 8 associated multicentric Castleman disease (HHV-8-associated MCD) is a subtype of Castleman disease (also known as giant lymph node hyperplasia, lymphoid hamartoma, or angiofollicular lymph node hyperplasia), a group of rare lymphoproliferative disorders characterized by lymph node enlargement, characteristic features on microscopic analysis of enlarged lymph node tissue, and a range of symptoms and clinical findings. People with human herpesvirus 8 associated multicentric Castelman disease (HHV-8-associated MCD) have enlarged lymph nodes in multiple regions and often have flu-like symptoms, abnormal findings on blood tests, and dysfunction of vital organs, such as the liver, kidneys, and bone marrow. HHV-8-associated MCD is known to be caused by uncontrolled infection with the human herpesvirus 8 virus (HHV-8) and is most frequently diagnosed in patients with human immunodeficiency virus (HIV). HHV-8-associated MCD is treated with a variety of medications, including immunosuppressants, chemotherapy, and antivirals. Castleman disease is named after Dr. Benjamin Castleman, who first described the disease in 1956. The Castleman Disease Collaborative Network is the largest organization focused on the disease and is involved in research, awareness, and patient support. ClassificationCastleman disease describes a group of at least 3 distinct disorders—unicentric Castleman disease (UCD), human herpesvirus 8 associated multicentric Castleman disease (HHV-8-associated MCD), and idiopathic multicentric Castleman disease (iMCD). Identifying the correct subtype of the disease is important, as the three disorders vary significantly in symptoms, clinical findings, disease mechanism, treatment approach, and prognosis.[1]
Signs and symptomsPeople with HHV-8-associated MCD may experience enlarged lymph nodes in multiple lymph node regions; systemic symptoms, such as fever, night sweats, unintended weight loss, and fatigue; rashes such as cherry hemangiomas or Kaposi sarcoma; enlargement of the liver and/or spleen; and extravascular fluid accumulation in the extremities (edema), abdomen (ascites), or lining of the lungs (pleural effusion).[2] Associated diseasesHHV-8-associated MCD is most commonly diagnosed in patients with human immunodeficiency virus (HIV), but can be seen in patients without HIV as well.[2] Patients with HHV-8-associated MCD are often found to have Kaposi sarcoma,[3] a cancer caused by the HHV-8 virus and most commonly seen in patients with HIV. Patients with HHV-8-associated MCD have been observed to be at greater risk of developing lymphoma.[4] CausesHHV-8-associated MCD is known to be caused by infection with human herpesvirus-8.[5] The HHV-8 virus is commonly found in healthy individuals showing no signs of disease,[6] but it is also known to cause diseases such as Kaposi sarcoma and HHV-8-associated MCD. Diseases caused by HHV-8 are seen most frequently in the setting of immune dysfunction related to factors such as HIV infection or use of immunosuppressant medications; however, HHV-8-associated diseases, including HHV-8-associated MCD, have been reported in otherwise healthy individuals.[2] MechanismIn HHV-8-associated MCD the HHV-8 virus infects B cells and plasmablasts in lymph nodes and causes infected cells to release proinflammatory cytokines, signaling molecules that increase the activity of immune cells. In particular, HHV-8 infection of immune cells leads to increased levels of Interleukin-6 (IL-6), a cytokine known to play a role in other forms of Castleman disease. The HHV-8 virus contains a gene coding for a viral variant of the IL-6 molecule. Cells infected by HHV-8 produce the viral variant of IL-6 and normal human IL-6, both of which contribute to the increased B cell proliferation and clinical findings seen in HHV-8-associated MCD.[5] DiagnosisHHV-8-associated MCD is diagnosed based on patient history, physical exam, laboratory testing, radiologic imaging, and microscopic analysis (histology) of biopsied tissue from an enlarged lymph node.[7] Formal criteria for the diagnosis of HHV-8-associated MCD have not been published; however, diagnosis requires enlargement of lymph nodes in multiple lymph node regions (typically confirmed with radiologic imaging), histologic changes consistent with HHV-8-associated MCD on biopsy of an enlarged lymph node, and confirmation of HHV-8 infection by LANA-1 lymph node staining or peripheral blood polymerase chain reaction for HHV-8.[7] HIV testing is useful for management, but a positive result is not necessary for to diagnose HHV-8-associated MCD.[2] Laboratory testingLaboratory testing may demonstrate low hemoglobin levels (anemia), abnormal platelet counts, low albumin levels, elevated inflammatory markers such as C-Reactive Protein, elevated creatinine (kidney dysfunction), increased levels of immunoglobulins, and elevation of molecules involved in inflammation (cytokines), such as interleukin 6 (IL-6).[3][8] Medical imagingRadiologic imaging will demonstrate enlarged lymph nodes in multiple regions, which are typically 18F-fluorodoxyglucose (FDG) avid on positron-emission tomography (PET).[9]PathologyUnlike the other subtypes of Castleman disease, UCD and iMCD, which can present with a spectrum of features on microscopic analysis (histology) of tissue biopsied from an enlarged lymph node, only a plasmablastic pattern of histologic features has been described in HHV-8-associated MCD. Plasmablastic features are similar to the plasmacytic features seen in iMCD and UCD, with both demonstrating increased plasma cells in interfollicular spaces. Plasmablastic features are differentiated from plasmacytic features by increased numbers of plasmablasts in follicular mantle zones.[10] Staining with latency-associated nuclear antigen (LANA-1), a marker for HHV-8 infection, is typically positive.[11] TreatmentData regarding treatment for HHV-8-associated MCD is limited and draws on a combination of observational case series and case reports. There have been no randomized controlled trials investigating treatment options for HHV-8-associated MCD. Surgical removal of enlarged lymph nodes, the standard treatment for UCD, is ineffective in HHV-8-associated MCD. Like iMCD, HHV-8-associated MCD is treated with medications. Factors influencing medication selection include disease severity, presence of HIV, presence of Kaposi sarcoma, and response to prior treatments.[12] Rituximab, a drug that depletes B cells, is the first line agent for patients with HHV-8-associated MCD and is recommended in all patients with proven HHV-8-associated MCD unless they have a contraindication to the medication or have failed treatment with the medication in the past. For patients who present with severe organ dysfunction, develop worsening organ dysfunction despite treatment with Rituximab, or have concurrent Kaposi sarcoma, additional chemotherapeutic agents are added to Rituximab. All patients with HIV should continue or initiate treatment with antiretroviral therapy. Antiviral medications targeted at HHV-8, such as valganciclovir, may be used in patients with poorly controlled HIV or concurrent Kaposi sarcoma.[12]Rituximab may be discontinued once clinical and laboratory evidence of active disease resolve or continued as maintenance therapy.[12] Patients who responded to Rituximab but have recurrent HHV-8-associated MCD after discontinuing the medication typically respond to retreatment with Rituximab.[3] Follow-upPatients with HHV-8-associated MCD are typically seen at routine intervals for assessment of treatment response and disease progression. Follow-up visits may include evaluation of symptoms, physical examination, laboratory testing, and radiologic imaging.[12] PrognosisOutcomes in HHV-8-associated MCD have improved significantly since treatment with rituximab has become more common. In one published case series from an experienced center, observed survival in a cohort of HIV patients with HHV-8-associated MCD was 94% at 2 years and 90% at 5 years.[3] EpidemiologyNo epidemiologic study has been published estimating the incidence for HHV-8-associated MCD in the general population. While rates of Kaposi sarcoma in HIV patients—which like HHV-8-associated MCD is caused by uncontrolled HHV-8 infection—decreased as treatment with antiretroviral therapy became more common, rates of HHV-8-associated MCD increased over the same time period.[13] There have been no published epidemiologic studies of Castleman disease outside of the United States; however, rates of HHV-8-associated MCD may vary in different populations based on the prevalence of HHV-8 infection. HistoryCastleman disease was first described by Dr. Benjamin Castleman in 1956.[14] In 1995, the association between HHV-8 and Castleman disease was described in patients with HIV.[15] World Castleman Disease Day was established in 2018. OrganizationsThe Castleman Disease Collaborative Network was founded in 2012 and is the largest organization focused on Castleman disease. It is a global collaborative network involved in research, awareness, and patient support.[16] References1. ^{{cite journal|display-authors=6|vauthors=Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS|date=March 2017|title=International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease|journal=Blood|volume=129|issue=12|pages=1646–1657|doi=10.1182/blood-2016-10-746933|pmc=5364342|pmid=28087540}} {{Medical resources|DiseasesDB=2165|ICD10={{ICD10|D47.Z2}}|ICD9={{ICD9|785.6}}|ICDO=|OMIM=|MedlinePlus=|eMedicineSubj=|eMedicineTopic=|MeshID=D005871}}2. ^1 2 {{cite journal | vauthors = Dossier A, Meignin V, Fieschi C, Boutboul D, Oksenhendler E, Galicier L | title = Human herpesvirus 8-related Castleman disease in the absence of HIV infection | journal = Clinical Infectious Diseases | volume = 56 | issue = 6 | pages = 833–42 | date = March 2013 | pmid = 23223599 | doi = 10.1093/cid/cis1009 }} 3. ^1 2 3 4 {{cite journal|vauthors=Bower M, Newsom-Davis T, Naresh K, Merchant S, Lee B, Gazzard B, Stebbing J, Nelson M|date=June 2011|title=Clinical Features and Outcome in HIV-Associated Multicentric Castleman's Disease|journal=Journal of Clinical Oncology|volume=29|issue=18|pages=2481–6|doi=10.1200/JCO.2010.34.1909|pmid=21555697|citeseerx=10.1.1.1019.8222}} 4. ^{{cite journal | vauthors = Oksenhendler E, Boulanger E, Galicier L, Du MQ, Dupin N, Diss TC, Hamoudi R, Daniel MT, Agbalika F, Boshoff C, Clauvel JP, Isaacson PG, Meignin V | title = High incidence of Kaposi sarcoma-associated herpesvirus-related non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease | journal = Blood | volume = 99 | issue = 7 | pages = 2331–6 | date = April 2002 | pmid = 11895764 | doi = 10.1182/blood.V99.7.2331 }} 5. ^1 {{cite journal | vauthors = Fajgenbaum DC, Shilling D | title = Castleman Disease Pathogenesis | journal = Hematology/Oncology Clinics of North America | volume = 32 | issue = 1 | pages = 11–21 | date = February 2018 | pmid = 29157613 | doi = 10.1016/j.hoc.2017.09.002 }} 6. ^{{cite journal | vauthors = Rabkin CS, Schulz TF, Whitby D, Lennette ET, Magpantay LI, Chatlynne L, Biggar RJ | title = Interassay correlation of human herpesvirus 8 serologic tests. HHV-8 Interlaboratory Collaborative Group | journal = The Journal of Infectious Diseases | volume = 178 | issue = 2 | pages = 304–9 | date = August 1998 | pmid = 9697708 | doi = 10.1086/515649 }} 7. ^1 {{cite journal | vauthors = Szalat R, Munshi NC | title = Diagnosis of Castleman Disease | journal = Hematology/Oncology Clinics of North America | volume = 32 | issue = 1 | pages = 53–64 | date = February 2018 | pmid = 29157619 | doi = 10.1016/j.hoc.2017.09.005 }} 8. ^{{cite journal|vauthors=Oksenhendler E, Carcelain G, Aoki Y, Boulanger E, Maillard A, Clauvel JP, Agbalika F|date=September 2000|title=High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric castleman disease in HIV-infected patients|journal=Blood|volume=96|issue=6|pages=2069–73|pmid=10979949}} 9. ^{{cite journal|vauthors=Barker R, Kazmi F, Stebbing J, Ngan S, Chinn R, Nelson M, O'Doherty M, Bower M|date=April 2009|title=FDG-PET/CT imaging in the management of HIV-associated multicentric Castleman's disease|journal=European Journal of Nuclear Medicine and Molecular Imaging|volume=36|issue=4|pages=648–52|doi=10.1007/s00259-008-0998-4|pmid=19050873}} 10. ^{{Cite journal|last=Dupin|first=N.|last2=Diss|first2=T. L.|last3=Kellam|first3=P.|last4=Tulliez|first4=M.|last5=Du|first5=M. Q.|last6=Sicard|first6=D.|last7=Weiss|first7=R. A.|last8=Isaacson|first8=P. G.|last9=Boshoff|first9=C.|date=2000-02-15|title=HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma|journal=Blood|volume=95|issue=4|pages=1406–1412|issn=0006-4971|pmid=10666218}} 11. ^{{cite journal|vauthors=Dupin N, Diss TL, Kellam P, Tulliez M, Du MQ, Sicard D, Weiss RA, Isaacson PG, Boshoff C|date=February 2000|title=HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma|journal=Blood|volume=95|issue=4|pages=1406–12|pmid=10666218}} 12. ^1 2 3 {{cite journal | vauthors = Bower M | title = How I treat HIV-associated multicentric Castleman disease | journal = Blood | volume = 116 | issue = 22 | pages = 4415–21 | date = November 2010 | pmid = 20688959 | doi = 10.1182/blood-2010-07-290213 }} 13. ^{{cite journal|vauthors=Powles T, Stebbing J, Bazeos A, Hatzimichael E, Mandalia S, Nelson M, Gazzard B, Bower M|date=April 2009|title=The role of immune suppression and HHV-8 in the increasing incidence of HIV-associated multicentric Castleman's disease|journal=Annals of Oncology|volume=20|issue=4|pages=775–9|doi=10.1093/annonc/mdn697|pmid=19179554}} 14. ^{{Cite journal|last=Castleman|first=B.|last2=Iverson|first2=L.|last3=Menendez|first3=V. P.|date=July 1956|title=Localized mediastinal lymphnode hyperplasia resembling thymoma|journal=Cancer|volume=9|issue=4|pages=822–830|issn=0008-543X|pmid=13356266|doi=10.1002/1097-0142(195607/08)9:4<822::AID-CNCR2820090430>3.0.CO;2-4}} 15. ^{{cite journal | vauthors = Soulier J, Grollet L, Oksenhendler E, Cacoub P, Cazals-Hatem D, Babinet P, d'Agay MF, Clauvel JP, Raphael M, Degos L | title = Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease | journal = Blood | volume = 86 | issue = 4 | pages = 1276–80 | date = August 1995 | pmid = 7632932 }} 16. ^{{Cite journal|last=Fajgenbaum|first=David C.|last2=Ruth|first2=Jason R.|last3=Kelleher|first3=Dermot|last4=Rubenstein|first4=Arthur H.|date=April 2016|title=The collaborative network approach: a new framework to accelerate Castleman's disease and other rare disease research|journal=The Lancet. Haematology|volume=3|issue=4|pages=e150–152|doi=10.1016/S2352-3026(16)00007-7|issn=2352-3026|pmid=27063967}} 2 : Immune system disorders|HIV/AIDS |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。