His Best Friend may refer to:

• His Best Friend (1918 film), a German silent film directed by Uwe Jens Krafft
• His Best Friend (1929 film), a German silent film directed by Harry Piel
• His Best Friend (1937 film), a German film remake, also directed by Piel
• His Best Friend (1962 film), a West German film directed by Luis Trenker

• Dwijen Sharma
• Dwi Joko Prihatin
• Dwikkoji
• Dwikora Harbour
• Dwi Kuswanto
• Dwik Vijayam
• Dwile Flonking
• D. Wiley Anderson
• D-Will
• D. willana
• Dwi-Madhyama Panchama Varja Ragas
• DW imaging
• Dwimmy
• Dwimordene
• DWIM-TV
• DWIN
• Dwina (disambiguation)
• Dwina, Virginia
• Dwindle
• Dwinell Grant
• Dwinell-Wright Company
• Dwingelderveld National Park
• Dwinger
• Dwinsk (disambiguation)
• DWINW