| 词条 | Hol118 family |
| 释义 |
The Listeria Phage A118 Holin (Hol118) Family (TC# 1.E.21) is a group of transporters belonging to the Holin Superfamily V.[1] A representative list of proteins belonging to the Hol118 family can be found in the Transporter Classification Database. Listeria monocytogenes bacteriophage A118 encodes a native holin, hol118, of 93 amino acyl residues (aas) exhibiting 3 putative transmembrane segments (TMSs). When cloned into lambda phage devoid of the S holin, it caused very late cell lysis, beginning 80 min. after induction.[2] Hol118 appeared in the cytoplasmic membrane shortly after infection. A second translational start codon (AUG-3) at nucleotide position 40 in the gene gives rise to a second gene product of 83 aas lacking TMS-1 (Hol118(83)). It is produced with the full length protein, appears in the membrane, but cannot support lambda lysis and inhibits lysis by Hol118. This dominant inhibitor presumably determines the time of lysis.[2] A homologue is found in L. innocua.The reaction probably catalyzed is: small molecules + autolysin (in) → small molecules + autolysin (out) See also
Further reading
References1. ^{{Cite journal|last=Reddy|first=Bhaskara L.|last2=Saier Jr.|first2=Milton H.|date=2013-11-01|title=Topological and phylogenetic analyses of bacterial holin families and superfamilies|journal=Biochimica et Biophysica Acta (BBA) - Biomembranes|volume=1828|issue=11|pages=2654–2671|doi=10.1016/j.bbamem.2013.07.004|pmc=3788059|pmid=23856191}} {{Portal bar|Molecular and Cellular Biology|border=no}}{{CCBYSASource|sourcepath=http://www.tcdb.org/search/result.php?tc=1.E.21|sourcearticle=1.E.21 The Listeria Phage A118 Holin (Hol118) Family|revision=699838558}}2. ^1 {{Cite journal|last=Vukov|first=Natasa|last2=Moll|first2=Isabella|last3=Bläsi|first3=Udo|last4=Scherer|first4=Siegfried|last5=Loessner|first5=Martin J.|date=2003-04-01|title=Functional regulation of the Listeria monocytogenes bacteriophage A118 holin by an intragenic inhibitor lacking the first transmembrane domain|journal=Molecular Microbiology|volume=48|issue=1|pages=173–186|issn=0950-382X|pmid=12657053|doi=10.1046/j.1365-2958.2003.03421.x}} 2 : Holins|Protein families |
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