| 词条 | Homoserine/threonine resistance transporter |
| 释义 |
| Symbol =RhtB | Name = Homoserine lactone efflux protein | image = | width = | caption = | Pfam =PF01810 | Pfam_clan = | InterPro =IPR004778. | SMART = | PROSITE = | SCOP = | TcdB = 2.A.76 | OPM family = | OPM protein = | PDB = }} The resistance to homoserine/threonine (RhtB) family (TC# 2.A.76) belongs to the lysine exporter (LysE) superfamily of transporters.[1] Hundreds of sequenced proteins, derived from Gram-negative and Gram-positive bacteria as well as archaea, comprise the RhtB family, but few of these proteins are functionally characterized.[2] MembersThe first two members of the RhtB family to be characterized functionally were the RhtB (TC# 2.A.76.1.1) and RhtC (TC# 2.A.76.1.2) permeases of E. coli.[3][4] E. coli possesses five paralogues, and a large region of one of them (YahN of E. coli; TC# 2.A.76.1.3) exhibits significant sequence similarity to YggA of E. coli (TC# 2.A.75.1.2), an established member of the LysE family (TC #2.A.75). The PSI-BLAST program groups the LysE family (TC# 2.A.75), the RhtB family and the CadD family (TC #2.A.77) together. These proteins are all of about the same size and apparent topology, further suggesting a common evolutionary origin.[2] The leucine exporter homologue (YeaS or LeuE; TC# 2.A.76.1.5) exports leucine and several other neutral, hydrophobic amino acids.[5] A representative list of proteins belonging to the RhtB family can be found in the Transporter Classification Database. General transport reactionThe transport reaction presumably catalyzed by members of the RhtB family is:[6] amino acid (in) + nH+ (out) ⇌ amino acid (out) + nH+ (in) See also
References1. ^{{cite journal | vauthors = Tsu BV, Saier MH | title = The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis | journal = PLOS One | volume = 10 | issue = 10 | pages = e0137184 | date = 2015-01-01 | pmid = 26474485 | pmc = 4608589 | doi = 10.1371/journal.pone.0137184 }} {{dual|source=Transporter Classification Database|sourcepath=http://www.tcdb.org/search/result.php?tc=2.A.76|sourcearticle=2.A.76 The Resistance to Homoserine/Threonine (RhtB) Family|author=Saier Lab Bioinformatics|date=25 February 2016}}{{membrane-protein-stub}}2. ^1 {{cite journal | vauthors = Vrljic M, Garg J, Bellmann A, Wachi S, Freudl R, Malecki MJ, Sahm H, Kozina VJ, Eggeling L, Saier MH, Eggeling L, Saier MH | title = The LysE superfamily: topology of the lysine exporter LysE of Corynebacterium glutamicum, a paradyme for a novel superfamily of transmembrane solute translocators | journal = Journal of Molecular Microbiology and Biotechnology | volume = 1 | issue = 2 | pages = 327–36 | date = November 1999 | pmid = 10943564 }} 3. ^{{cite journal | vauthors = Aleshin VV, Zakataeva NP, Livshits VA | title = A new family of amino-acid-efflux proteins | journal = Trends in Biochemical Sciences | volume = 24 | issue = 4 | pages = 133–5 | date = April 1999 | pmid = 10322417 | doi = 10.1016/s0968-0004(99)01367-5 }} 4. ^{{cite journal | vauthors = Zakataeva NP, Aleshin VV, Tokmakova IL, Troshin PV, Livshits VA | title = The novel transmembrane Escherichia coli proteins involved in the amino acid efflux | journal = FEBS Letters | volume = 452 | issue = 3 | pages = 228–32 | date = June 1999 | pmid = 10386596 | doi = 10.1016/s0014-5793(99)00625-0 }} 5. ^{{cite journal | vauthors = Kutukova EA, Livshits VA, Altman IP, Ptitsyn LR, Zyiatdinov MH, Tokmakova IL, Zakataeva NP | title = The yeaS (leuE) gene of Escherichia coli encodes an exporter of leucine, and the Lrp protein regulates its expression | journal = FEBS Letters | volume = 579 | issue = 21 | pages = 4629–34 | date = August 2005 | pmid = 16098526 | doi = 10.1016/j.febslet.2005.07.031 }} 6. ^{{Cite web| url = http://www.tcdb.org/search/result.php?tc=2.A.76| title = TCDB » SEARCH| website = www.tcdb.org| access-date = 2016-02-25}} 2 : Protein families|Solute carrier family |
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