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词条 Huh7
释义

  1. References

  2. External links

{{technical|date=August 2016}}Huh7 is a type of human liver cell line that may be grown in the laboratory for research purposes. According to the web site huh7.com, it is "a well differentiated hepatocyte-derived carcinoma cell line, originally taken from a liver tumor in a 57-year-old Japanese male in 1982."[1] It is used extensively in hepatitis C and dengue virus research.[2][3]

Huh7 cells have been instrumental in hepatitis C research. Until 2005, it was not possible to culture hepatitis C in the laboratory. The introduction of the Huh7 cell line permitted screening of drug candidates against laboratory-cultured hepatitis C virus and permitted the development of new drugs against hepatitis C.[4][2][5]

References

1. ^{{cite web|title=HuH-7 Cell Line|url=http://huh7.com/|accessdate=2016-07-05}}
2. ^{{cite journal|title=Three-dimensional Huh7 cell culture system for the study of Hepatitis C virus infection|journal=Virology Journal|year=2009|volume=6|page=103|doi=10.1186/1743-422X-6-103|pmid=19604376|pmc=2719612|last1=Sainz|first1=Bruno|last2=Tencate|first2=Veronica|last3=Uprichard|first3=Susan L}}
3. ^{{cite journal|title=The medicinal chemistry of dengue virus|journal=Journal of Medicinal Chemistry|volume=59|issue=12|pages=5622|year=2016|doi=10.1021/acs.jmedchem.5b01653|pmid=26771861|last1=Behnam|first1=Mira A. M.|last2=Nitsche|first2=Christoph|last3=Boldescu|first3=Veaceslav|last4=Klein|first4=Christian D.}}
4. ^{{cite journal|title=Efficient hepatitis C virus cell culture system: what a difference the host cell makes|pmc=1175013|pmid=15998731|journal=Proceedings of the National Academy of Sciences of the United States of America|year=2005|volume=102|issue=28|pages=9739–40|author1=Bartenschlager|first1=R|last2=Pietschmann|first2=T|doi=10.1073/pnas.0504296102}}
5. ^{{cite journal|year=2009|volume=7|issue=3|pages=329–50|doi=10.1586/eri.09.12|pmid=19344246|title=Hepatitis C virus virology and new treatment targets|journal=Expert Review of Anti-infective Therapy|last1=Meier|first1=Volker|last2=Ramadori|first2=Giuliano}}

External links

  • [https://web.expasy.org/cellosaurus/CVCL_0336 Cellosaurus entry for Huh7]

1 : Human cell lines

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