| 词条 | Human polyomavirus 12 |
| 释义 |
| name = Human polyomavirus 12 | virus_group = i | familia = Polyomaviridae | species = Human polyomavirus 12 }}Human polyomavirus 12 (HPyV12) is a virus of the polyomavirus family that infects human hosts. It was discovered and reported in 2013 after isolation from the organs of the gastrointestinal tract, particularly the liver.[1] DiscoveryHPyV12 was first discovered in 2013 by generic PCR used to screen samples of the organs of the gastrointestinal tract. HPyV12 was identified first and most commonly in liver samples; it was also occasionally detected in the colon and rectum and in feces.[1] TaxonomyThe HPyV12 genome follows the typical organization for a polyomavirus, containing a small and large tumor antigen and three viral capsid proteins; it has no open reading frame corresponding to an agnoprotein. In the 2015 taxonomic update to the polyomavirus group, the International Committee on Taxonomy of Viruses classified HPyV12 as a member of the genus Alphapolyomaviridae, whose type species is murine polyomavirus (Mus musculus polyomavirus 1).[2] PrevalenceThe prevalence of HPyV12 is not well characterized. A survey of seroprevalence — that is, prevalence of detectable antibodies against viral proteins indicating either past or present exposure — found that between 15–33% of healthy adults exhibited evidence of exposure, with slightly lower rates in children.[1] Clinical manifestationsThere is no known clinical significance associated with HPyV12.[3] References1. ^1 2 {{cite journal|last1=Korup|first1=Sarah|last2=Rietscher|first2=Janita|last3=Calvignac-Spencer|first3=Sébastien|last4=Trusch|first4=Franziska|last5=Hofmann|first5=Jörg|last6=Moens|first6=Ugo|last7=Sauer|first7=Igor|last8=Voigt|first8=Sebastian|last9=Schmuck|first9=Rosa|last10=Ehlers|first10=Bernhard|last11=Qiu|first11=Jianming|title=Identification of a Novel Human Polyomavirus in Organs of the Gastrointestinal Tract|journal=PLoS ONE|date=13 March 2013|volume=8|issue=3|pages=e58021|doi=10.1371/journal.pone.0058021|pmid=23516426|pmc=3596337}} {{Human polyomaviruses}}{{Taxonbar|from=Q24809426}}{{Use dmy dates|date=April 2017}}2. ^{{cite journal|last1=Polyomaviridae Study Group of the International Committee on Taxonomy of|first1=Viruses|last2=Calvignac-Spencer|first2=S|last3=Feltkamp|first3=MC|last4=Daugherty|first4=MD|last5=Moens|first5=U|last6=Ramqvist|first6=T|last7=Johne|first7=R|last8=Ehlers|first8=B|title=A taxonomy update for the family Polyomaviridae|journal=Archives of Virology|date=29 February 2016|doi=10.1007/s00705-016-2794-y|pmid=26923930|volume=161|issue=6|pages=1739–50}} 3. ^{{cite journal|last1=Rinaldo|first1=Christine Hanssen|last2=Hirsch|first2=Hans H.|title=The human polyomaviruses: from orphans and mutants to patchwork family|journal=APMIS|date=August 2013|volume=121|issue=8|pages=681–4|doi=10.1111/apm.12125 |pmid=23781946}} 1 : Polyomaviridae |
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