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词条 Hyaladherin
释义

  1. See also

  2. References

Hyaladherins, also known as hyaluronan-binding proteins, are proteins capable of binding to hyaluronic acid. Most hyaladherins belong to the Link module superfamily, including its main receptor CD44, hyalectans and TSG-6.[1] In addition there is a diverse group of hyaladherins lacking a Link module; these include the receptor RHAMM, C1QBP (HABP1) and HABP2.[2] The primary roles of hyaladherins are cell adhesion, structural support of the extracellular matrix (ECM) and cell signalling.[2]

Due to the role of aberrant hyaluronic acid synthesis and degradation in various cancers, hyaladherins, as well as hyaluronic acid, are considered a promising target for cancer therapy.[3]

See also

  • Hyaluronan synthase
  • Hyaluronidase

References

1. ^{{cite journal|last1=Toole|first1=B.P.|title=Hyaluronan and its binding proteins, the hyaladherins|journal=Current Opinion in Cell Biology|date=October 1990|volume=2|issue=5|pages=839–844|doi=10.1016/0955-0674(90)90081-O}}
2. ^{{cite journal|last1=Day|first1=A. J.|last2=Prestwich|first2=G. D.|title=Hyaluronan-binding Proteins: Tying Up the Giant|journal=Journal of Biological Chemistry|date=20 November 2001|volume=277|issue=7|pages=4585–4588|doi=10.1074/jbc.R100036200|pmid=11717315}}
3. ^{{cite journal|last1=Nikitovic|first1=Dragana|last2=Kouvidi|first2=Katerina|last3=Kavasi|first3=Rafaela-Maria|last4=Berdiaki|first4=Aikaterini|last5=N. Tzanakakis|first5=George|title=Hyaluronan/Hyaladherins - a Promising Axis for Targeted Drug Delivery in Cancer|journal=Current Drug Delivery|date=21 May 2016|volume=13|issue=4|pages=500–511|doi=10.2174/1567201813666151109103013}}

1 : Proteins by function

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