“Hydrofunctionalization”的意思、由来-开放百科全书

词条

Hydrofunctionalization

释义

Examples
References

A hydrofunctionalization reaction is the addition of hydrogen and another univalent fragment (X) across a carbon-carbon or carbon-heteroatom multiple bond.^[1] Often, the term hydrofunctionalization without modifier refers specifically to the use of the covalent hydride (H-X) as the source of hydrogen and X for this transformation. If other reagents are used to achieve the net addition of hydrogen and X across a multiple bond, the process may be referred to as a formal hydrofunctionalization.

For terminal olefins (or acetylenes), the regioselectivity of the process can be described as Markovnikov (addition of X at the substituted end) or anti-Markovnikov (addition of X at the unsubstituted end). Catalysts are frequently employed to control the chemo-, regio-, and stereoselectivity of hydrofunctionalization reactions.

Examples

Some of the better known classes of hydrofunctionalization reactions include the following:

Hydroboration
Hydrosilylation
Hydrometalation (including both transition or main group metal hydrides)
Hydroamination
(Olefin) hydration (addition of H₂O across a double bond)
Hydroalkoxylation (also known as hydroetherification)
Hydrohalogenation
Hydrovinylation (including hydroarylation and olefin dimerization and others)
Hydroacylation
Hydroformylation (refers specifically to the addition of CHO and H using H₂ and CO as reagents, also known as the oxo process)

References

1. ^{{Cite book|title=Hydrofunctionalization - Springer|volume = 43|doi=10.1007/978-3-642-33735-2|series = Topics in Organometallic Chemistry|year = 2013|isbn = 978-3-642-33734-5}}

1 : Chemistry

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