| 词条 | IPTBO |
| 释义 |
| Name = IPTBO | ImageFile = Isopropylbicyclophosphate.svg | ImageSize = 120px | ImageFile1 = IPTBO_3D_structure.png | IUPACName = 4-Isopropyl-2,6,7-trioxa-1-phosphatbicyclo(2,2,2)octane-1-oxide | OtherNames = 4-Isopropylbicyclophosphate | Section1 = {{Chembox Identifiers | CASNo = 51052-72-3 | ChemSpiderID = 36478 | PubChem = 39891 | StdInChI=1S/C7H13O4P/c1-6(2)7-3-9-12(8,10-4-7)11-5-7/h6H,3-5H2,1-2H3 | StdInChIKey = CIEZMYRJRCLYNF-UHFFFAOYSA-N | SMILES = CC(C)C12COP(=O)(OC1)OC2 }} | Section2 = {{Chembox Properties | C=7|H=13|O=4|P=1 }} | Section7 = {{Chembox Hazards | MainHazards = Extremely toxic | LD50 = 180 μg/kg (mice)[1] }} }}IPTBO (isopropylbicyclophosphate) is a bicyclic phosphate convulsant.[2] It is an extremely potent GABA receptor antagonist that can cause violent convulsions in mice.[3][4] See also
References1. ^{{cite journal |last1=Milbrath |first1=Dean S. |last2=Engel |first2=Judith L. |last3=Verkade |first3=John G. |last4=Casida |first4=John E. |title=Structure-toxicity relationships of 1-substituted-4-alkyl-2,6,7-trioxabicyclo[2.2.2.]octanes |journal=Toxicology and Applied Pharmacology |date=February 1979 |volume=47 |issue=2 |pages=287–293 |doi=10.1016/0041-008x(79)90323-5 |pmid=452023}} {{GABA receptor modulators}}{{Neurotoxins}}{{Convulsants}}{{Neurotoxin-stub}}2. ^{{cite journal|title=Bicyclic phosphates increase the cyclic GMP level in rat cerebellum, presumably due to reduced GABA inhibition|journal=Brain Research|volume=181|issue=1|pages=175–84|doi=10.1016/0006-8993(80)91267-6|pmid=6243222|year=1980|last1=Mattsson|first1=Hillevi}} 3. ^{{cite journal|title=The effect of various drug pretreatments on the convulsions and cerebellar cyclic nucleotide changes induced by the convulsant 4-isopropyl-2,6,7-trioxa-1-phosphatbicyclo(2,2,2)octane-1-oxide(IPTBO)|journal=Brain Research|volume=181|issue=1|pages=175–84|doi=10.1016/0006-8993(80)91267-6|pmid=6243222|year=1980|last1=Mattsson|first1=Hillevi}} 4. ^{{cite journal|title=Effects of dose and time after administration of 4-isopropyl-2,6,7-trioxa-1-phosphabicyclo (2,2,2)octane-1-oxide (IPTBO) on cyclic nucleotide concentrations in mouse cerebellum|journal=Neurochemistry International|volume=6|issue=4|pages=453|doi=10.1016/0197-0186(84)90114-1|pmid=20488068|year=1984|last1=Blenkinsop|first1=I.S|last2=Coult|first2=D.B|last3=Davies|first3=W.E|last4=Howells|first4=D.J}} 6 : Bicyclic phosphates|Convulsants|Neurotoxins|Isopropyl compounds|Oxygen heterocycles|GABAA receptor negative allosteric modulators |
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