“Jean-Pierre Kinet”的意思、由来-开放百科全书

Dr. Kinet was born and raised in Tilff-Esneux, Belgium. and trained as a physician in Belgium. He completed a bachelor’s degree in Medicine cum laude from the University of Namur, Belgium, and obtained his M.D. magna cum laude from the University of Liège, Belgium, in 1979. From 1979-1982, he completed a residency in internal medicine, also at the University of Liège, while conducting research in hematology and nephrology.

In 1982, Dr. Kinet began a post-doctoral fellowship at the National Institutes of Health (NIH) in the lab of Henry Metzger^[3] where he cloned and characterized the beta subunit of the Fc Receptor for Immunoglobulin E,^[4] an important component of the immune response against parasitic infections and the allergic and anaphylactic responses. In 1989, Dr. Kinet was appointed Head of the Molecular Allergy and Immunology Section at the National Institute of Allergy and Infectious Diseases, NIH. His laboratory continued to characterize the biology of the Fc𝛆RI receptor, elucidating key aspects of its gene regulation, antigen recognition, and intracellular signal transduction mechanisms.^[5]^[6] In 1995, Dr. Kinet moved to Harvard Medical School, where he was appointed Professor of Pathology.^[2] While continuing to investigate Fc𝛆RI biology, his lab also began to study calcium signaling in immune cells. This work eventually led to the identification of key channel proteins involved in calcium signaling in immune and other non-neuronal cell types ^[7]^[8]^[9]^[10]^[11]

References

1. ^{{Cite journal|last=Vig|first=Monika|last2=Kinet|first2=Jean-Pierre|date=January 2009|title=Calcium signaling in immune cells|journal=Nature Immunology|volume=10|issue=1|pages=21–27|doi=10.1038/ni.f.220|issn=1529-2916|pmc=2877033|pmid=19088738}}
2. ^¹{{Cite web|url=http://dms.hms.harvard.edu/immunology/fac/Kinet.php|title=Harvard Immunology PhD Program|website=dms.hms.harvard.edu|access-date=2018-10-31}}
3. ^{{Cite web|url=https://www.aai.org/About/History/Past-Presidents-and-Officers/HenryMetzger|title=The American Association of Immunologists - Henry Metzger|last=|first=|date=|website=|archive-url=|archive-date=|dead-url=|access-date=}}
4. ^{{Cite journal|last=Kinet|first=J. P.|last2=Blank|first2=U.|last3=Ra|first3=C.|last4=White|first4=K.|last5=Metzger|first5=H.|last6=Kochan|first6=J.|date=September 1988|title=Isolation and characterization of cDNAs coding for the beta subunit of the high-affinity receptor for immunoglobulin E|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=85|issue=17|pages=6483–6487|issn=0027-8424|pmid=2970642|pmc=281997}}
5. ^{{Cite journal|last=Blank|first=U.|last2=Ra|first2=C.|last3=Miller|first3=L.|last4=White|first4=K.|last5=Metzger|first5=H.|last6=Kinet|first6=J. P.|date=1989-01-12|title=Complete structure and expression in transfected cells of high affinity IgE receptor|journal=Nature|volume=337|issue=6203|pages=187–189|doi=10.1038/337187a0|issn=0028-0836|pmid=2521376}}
6. ^{{Cite journal|last=Miller|first=L.|last2=Blank|first2=U.|last3=Metzger|first3=H.|last4=Kinet|first4=J. P.|date=1989-04-21|title=Expression of high-affinity binding of human immunoglobulin E by transfected cells|journal=Science|volume=244|issue=4902|pages=334–337|issn=0036-8075|pmid=2523561}}
7. ^{{Cite journal|last=Vig|first=M.|last2=Peinelt|first2=C.|last3=Beck|first3=A.|last4=Koomoa|first4=D. L.|last5=Rabah|first5=D.|last6=Koblan-Huberson|first6=M.|last7=Kraft|first7=S.|last8=Turner|first8=H.|last9=Fleig|first9=A.|date=2006-05-26|title=CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry|journal=Science|volume=312|issue=5777|pages=1220–1223|doi=10.1126/science.1127883|issn=1095-9203|pmc=5685805|pmid=16645049}}
8. ^{{Cite journal|last=Launay|first=Pierre|last2=Cheng|first2=Henrique|last3=Srivatsan|first3=Subhashini|last4=Penner|first4=Reinhold|last5=Fleig|first5=Andrea|last6=Kinet|first6=Jean-Pierre|date=2004-11-19|title=TRPM4 regulates calcium oscillations after T cell activation|journal=Science|volume=306|issue=5700|pages=1374–1377|doi=10.1126/science.1098845|issn=1095-9203|pmid=15550671}}
9. ^{{Cite journal|last=Peinelt|first=Christine|last2=Vig|first2=Monika|last3=Koomoa|first3=Dana L.|last4=Beck|first4=Andreas|last5=Nadler|first5=Monica J. S.|last6=Koblan-Huberson|first6=Murielle|last7=Lis|first7=Annette|last8=Fleig|first8=Andrea|last9=Penner|first9=Reinhold|date=July 2006|title=Amplification of CRAC current by STIM1 and CRACM1 (Orai1)|journal=Nature Cell Biology|volume=8|issue=7|pages=771–773|doi=10.1038/ncb1435|issn=1465-7392|pmc=5685802|pmid=16733527}}
10. ^{{Cite journal|last=Vig|first=Monika|last2=DeHaven|first2=Wayne I.|last3=Bird|first3=Gary S.|last4=Billingsley|first4=James M.|last5=Wang|first5=Huiyun|last6=Rao|first6=Patricia E.|last7=Hutchings|first7=Amy B.|last8=Jouvin|first8=Marie-Hélène|last9=Putney|first9=James W.|date=January 2008|title=Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels|journal=Nature Immunology|volume=9|issue=1|pages=89–96|doi=10.1038/ni1550|issn=1529-2916|pmc=2377025|pmid=18059270}}
11. ^{{Cite journal|last=Wang|first=Huiyun|last2=Zhang|first2=Xuexin|last3=Xue|first3=Li|last4=Xing|first4=Juan|last5=Jouvin|first5=Marie-Hélène|last6=Putney|first6=James W.|last7=Anderson|first7=Matthew P.|last8=Trebak|first8=Mohamed|last9=Kinet|first9=Jean-Pierre|date=2016-04-19|title=Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles|journal=Immunity|volume=44|issue=4|pages=782–794|doi=10.1016/j.immuni.2016.01.015|issn=1097-4180|pmid=27037192}}