“2,4-diaminopentanoate dehydrogenase”的意思、由来-开放百科全书

词条

2,4-diaminopentanoate dehydrogenase

释义

References

{{enzyme
| Name = 2,4-diaminopentanoate dehydrogenase
| EC_number = 1.4.1.12
| CAS_number = 39346-26-4
| IUBMB_EC_number = 1/4/1/12
| GO_code = 0047530
| image =
| width =
| caption =
}}

In enzymology, a 2,4-diaminopentanoate dehydrogenase ({{EC number|1.4.1.12}}) is an enzyme that catalyzes the chemical reaction

2,4-diaminopentanoate + H₂O + NAD(P)+ 2-amino-4-oxopentanoate + NH₃ + NAD(P)H + H⁺

The 4 substrates of this enzyme are 2,4-diaminopentanoate, H₂O, NAD⁺, and NADP⁺, whereas its 5 products are 2-amino-4-oxopentanoate, NH₃, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating). This enzyme is also called 2,4-diaminopentanoic acid C4 dehydrogenase. This enzyme participates in 3 metabolic pathways: lysine degradation, arginine and proline metabolism, and d-arginine and d-ornithine metabolism.

References

{{cite journal |vauthors=Somack R, Costilow RN | date = 1973 | title = 2,4-diaminopentanoic acid C 4 dehydrogenase. Purification and properties of the protein | journal = J. Biol. Chem. | volume = 248 | pages = 385–8 | pmid = 4684685 | issue = 2 }}
{{cite journal | author = Stadtman TC | date = 1973 | title = Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase) | journal = Adv. Enzymol. Relat. Areas Mol. Biol. | volume = 38 | pages = 441–445 }}
{{cite journal |vauthors=Tsuda Y, Friedmann HC | date = 1970 | title = Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide | journal = J. Biol. Chem. | volume = 245 | pages = 5914–26 | pmid = 4394942 | issue = 22 }}

4 : EC 1.4.1|NADPH-dependent enzymes|NADH-dependent enzymes|Enzymes of unknown structure

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