“2,6-dioxo-6-phenylhexa-3-enoate hydrolase”的意思、由来-开放百科全书

词条

2,6-dioxo-6-phenylhexa-3-enoate hydrolase

释义

Structural studies
References

{{enzyme
| Name = 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
| EC_number = 3.7.1.8
| CAS_number = 102925-38-2
| IUBMB_EC_number = 3/7/1/8
| GO_code = 0018774
| image =
| width =
| caption =
}}

In enzymology, a 2,6-dioxo-6-phenylhexa-3-enoate hydrolase ({{EC number|3.7.1.8}}) is an enzyme that catalyzes the chemical reaction

2,6-dioxo-6-phenylhexa-3-enoate + H₂O benzoate + 2-oxopent-4-enoate

Thus, the two substrates of this enzyme are 2,6-dioxo-6-phenylhexa-3-enoate and H₂O, whereas its two products are benzoate and 2-oxopent-4-enoate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-carbon bonds in ketonic substances. The systematic name of this enzyme class is 2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase. This enzyme is also called HOHPDA hydrolase. This enzyme participates in biphenyl degradation and fluorene degradation.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1C4X}}, {{PDB link|1J1I}}, and {{PDB link|2OG1}}.

References

{{cite journal |vauthors=Omori T, Sugimura K, Ishigooka H, Minoda Y | date = 1986 | title = Purification and some properties of a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolyzing enzyme from Pseudomonas cruciviae S93 B1 involved in the degradation of biphenyl | journal = Agric. Biol. Chem. | volume = 50 | pages = 931–937 | doi=10.1271/bbb1961.50.931}}

2 : EC 3.7.1|Enzymes of known structure

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