“2-dehydropantolactone reductase (A-specific)”的意思、由来-开放百科全书

词条

2-dehydropantolactone reductase (A-specific)

释义

References

{{enzyme
| Name = 2-dehydropantolactone reductase (A-specific)
| EC_number = 1.1.1.168
| CAS_number = 37211-75-9
| IUBMB_EC_number = 1/1/1/168
| GO_code = 0047011
| image =
| width =
| caption =
}}

In enzymology, a 2-dehydropantolactone reductase (A-specific) ({{EC number|1.1.1.168}}) is an enzyme that catalyzes the chemical reaction

(R)-pantolactone + NADP⁺ 2-dehydropantolactone + NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-pantolactone and NADP⁺, whereas its 3 products are 2-dehydropantolactone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-pantolactone:NADP⁺ oxidoreductase (A-specific). Other names in common use include 2-oxopantoyl lactone reductase, ketopantoyl lactone reductase, 2-ketopantoyl lactone reductase, and 2-dehydropantoyl-lactone reductase (A-specific).

References

{{cite journal | vauthors = ((King HL Jr)), Dyar RE, Wilken DR | date = Aug 10, 1974 | title = Ketopantoyl lactone and ketopantoic acid reductases: Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase | journal = J. Biol. Chem. | volume = 249 | issue = 15 | pages = 4689–4695 |pmid = 4603075}}
{{cite journal |vauthors=Wilken DR, ((King HL Jr)), Dyar RE | date = March 25, 1975 | title = Ketopantoic acid and ketopantoyl lactone reductases: Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate | journal = J. Biol. Chem. | volume = 250 | issue = 6 | pages = 2311–2314 | pmid = 234966 }}

3 : EC 1.1.1|NADPH-dependent enzymes|Enzymes of unknown structure

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