“2-hydroxymethylglutarate dehydrogenase”的意思、由来-开放百科全书

词条

2-hydroxymethylglutarate dehydrogenase

释义

References

{{enzyme
| Name = 2-hydroxymethylglutarate dehydrogenase
| EC_number = 1.1.1.291
| CAS_number =
| IUBMB_EC_number = 1/1/1/291
| GO_code = 0043718
| image =
| width =
| caption =
}}

In enzymology, a 2-hydroxymethylglutarate dehydrogenase ({{EC number|1.1.1.291}}) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxymethylglutarate + NAD⁺ 2-formylglutarate + NADH + H⁺

Thus, the two substrates of this enzyme are (S)-2-hydroxymethylglutarate and NAD⁺, whereas its 3 products are 2-formylglutarate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-2-hydroxymethylglutarate:NAD⁺ oxidoreductase. This enzyme is also called HgD.

References

{{cite journal |vauthors=Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ | date = 2006 | title = Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | pages = 12341–6 | pmid = 16894175 | doi = 10.1073/pnas.0601635103 | issue = 33 | pmc = 1562527 }}

3 : EC 1.1.1|NADH-dependent enzymes|Enzymes of unknown structure

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