“2-methylacyl-CoA dehydrogenase”的意思、由来-开放百科全书

词条

2-methylacyl-CoA dehydrogenase

释义

References

{{enzyme
| Name = 2-methylacyl-CoA dehydrogenase
| EC_number = 1.3.99.12
| CAS_number = 85130-32-1
| IUBMB_EC_number = 1/3/99/12
| GO_code = 0003853
| image =
| width =
| caption =
}}

In enzymology, a 2-methylacyl-CoA dehydrogenase ({{EC number|1.3.99.12}}) is an enzyme that catalyzes the chemical reaction

2-methylbutanoyl-CoA + acceptor 2-methylbut-2-enoyl-CoA + reduced acceptor

Thus, the two substrates of this enzyme are 2-methylbutanoyl-CoA and acceptor, whereas its two products are 2-methylbut-2-enoyl-CoA and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 2-methylbutanoyl-CoA:acceptor oxidoreductase. Other names in common use include branched-chain acyl-CoA dehydrogenase, 2-methyl branched chain acyl-CoA dehydrogenase, and 2-methylbutanoyl-CoA:(acceptor) oxidoreductase. This enzyme participates in valine, leucine and isoleucine degradation.

References

{{cite journal |vauthors=Ikeda Y, Dabrowski C, Tanaka K | date = 1983 | title = Separation and properties of five distinct acyl-CoA dehydrogenases from rat liver mitochondria. Identification of a new 2-methyl branched chain acyl-CoA dehydrogenase | journal = J. Biol. Chem. | volume = 258 | pages = 1066–76 | pmid = 6401712 | issue = 2 }}

2 : EC 1.3.99|Enzymes of unknown structure

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